Now showing items 1-8 of 8

    • Assessment of Interleukin-1 Gene Cluster Polymorphisms in Lone Atrial Fibrillation: New Insight into the Role of Inflammation in Atrial Fibrillation 

      Çoker Gürkan, Ajda; Güngör, Barış; Ekmekçi, Ahmet; Arman, Ahmet; Özcan, Kazım S.; Üçer, Ekrem; Çalık, Nazmi; Yılmaz, Hale; Tezel, Tuna; Bolca, Osman (Wiley-Blackwell, 111 River St, Hoboken 07030-5774, Nj USA, 2013-10)
      BackgroundSystemic inflammation is accepted as one of the pathophysiological mechanisms of atrial fibrillation (AF). The role of inflammation has been shown previously. Interleukin (IL) system is the main modulator of the ...
    • Association Between Sporadic Parkinson Disease And Interleukin-1 Beta-511 Gene Polymorphisms In The Turkish Population 

      Arman, Ahmet; Işık, Nihal; Candan, Fatma; Becit, Kezban Serap; List, Edward O.; Çoker, Ajda (John Libbey Eurotext Ltd, 127 Ave De La Republique, 92120 Montrouge, France, 2010-06)
      The pathogenesis of Parkinson Disease (PD) remains poorly understood; however, inflammation is thought to play an important role in disease progression. Recent reports suggest that IL-1, a major proinflammatory cytokine, ...
    • Cathepsin K analysis in a pycnodysostosis cohort: demographic, genotypic and phenotypic features 

      Arman, Ahmet; Bereket, Abdullah; Çoker Gürkan, Ajda; Şimşek Kiper, Pelin Özlem; Güran, Tülay; Özkan, Behzat; Atay, Zeynep; Akçay, Teoman; Haliloğlu, Belma; Boduroğlu, Koray; Alanay, Yasemin; Turan, Serap (Biomed Central Ltd, 236 Grays Inn Rd, Floor 6, London Wc1X 8Hl, England, 2014-04-26)
      Background: To characterize cathepsin K (CTSK) mutations in a group of patients with pycnodysostosis, who presented with either short stature or atypical fractures to pediatric endocrinology or dysmorphic features to ...
    • Characterization of GH-1 Mutations in Children with Isolated Growth Hormone Deficiency in the Turkish Population 

      Çoker, Ajda; Çetinkaya, Ergun; Dündar, Bumin; Şıklar, Zeynep; Büyükgebiz, Atilla; Arman, Ahmet (FREUND PUBLISHING HOUSE LTD, PO BOX 35010, TEL AVIV 61350, ISRAEL, 2009-10)
      Isolated growth hormone deficiency (IGHD) is defined as a medical condition associated with growth failure due to insufficient production of growth hormone (GH) or lack of growth hormone action. It occurs with an incidence ...
    • Human growth hormone 

      Çoker, Ajda; Arman, Ahmet (İstanbul Kültür Üniversitesi, 2009)
      Growth hormone (GH), is expressed from anterior pituitary gland as a 191 amino acid long polypeptide hormone, has essential role on postnatal growth. In addition to longitudinal growth, GH has various effects on ...
    • Lack Of Association Between IL-6 Gene Polymorphisms And Rheumatoid Arthritis In Turkish Population 

      Çoker, Ajda; Arman, Ahmet; Sarıöz, Özlem; İnanç, Nevsun; Direskeneli, Rafi Haner (Springer Heidelberg, Tiergartenstrasse 17, D-69121 Heidelberg, Germany, 2012-07)
      Inflammatory cytokines play an important role in the pathogenesis of rheumatoid arthritis (RA). One of candidate genes is interleukin-6 (IL-6), and single-nucleotide polymorphisms in the promoter region of IL-6 were found ...
    • Multiple Sclerosis: Association with the Interleukin-1 Gene Family Polymorphisms in the Turkish Population 

      Çoker Gürkan, Ajda; Işık, Nihal; Arman, Ahmet; Aydın Cantürk, İlknur; Candan, Fatma; Aktan, Şule; Erzaim, Nilüfer; Arıcı Düz, Özge; Aydın, Tuğrul; Türkeş, Muzaffer (Informa Healthcare, Telephone House, 69-77 Paul Street, London Ec2A 4Lq, England, 2013-10)
      Background: Multiple Sclerosis (MS) is a neurodegenerative disease. It involves inflammation and demyelination. Since cytokines play an important role in the development of MS, genes encoding cytokines such as the Interleukin ...
    • Novel Growth Hormone Receptor Gene Mutation in a Patient with Laron Syndrome 

      Arman, Ahmet; Yüksel, Bilgin; Çoker, Ajda; Sarıöz, Özlem; Temiz, Fatih; Topaloğlu, Ali Kemal (Freund Publishing House Ltd, Po Box 35010, Tel Aviv 61350, israel, 2010-04)
      Growth Hormone (GH) is a 22 kDa protein that has effects on growth and glucose and fat metabolisms. These effects are initiated by binding of growth hormone (GH) to growth hormone receptors (GHR) expressed in target cells. ...