Show simple item record

dc.contributor.authorUslan, Canan
dc.contributor.authorDurmuş İşleyen, Naciye
dc.contributor.authorÖztürk, Yetkin
dc.contributor.authorTuranlı Yıldız, Burcu
dc.contributor.authorÇakar, Zeynep Petek
dc.contributor.authorGöksel Şahin, Meltem
dc.contributor.authorDurmuş, Mahmut
dc.contributor.authorHepüzer Gürsel, Yeşim
dc.contributor.authorSesalan, Behice Şebnem
dc.description.abstractA poly(ethylene glycol) (PEG)-conjugated silicon(IV) phthalocyanine axially substituted with (PEG1000) chains (SiPc-PEG) was synthesized, and this novel phthalocyanine was characterized by H-1-NMR, FT-IR and UV-Vis spectrophotometric methods. Elemental analysis data were beneficial for the evaluation of the chemical structure of the new compound. The total number of (O-CH2-CH2 units was calculated as 44 and the structure of the new PEG-conjugated silicon phthalocyanine was determined by the use of integral areas in H-1-NMR spectrum and the ratio of SiPc: PEG1000 was found as 1:2. The photophysical and photochemical properties were determined in both DMSO and aqueous solutions. In addition, the photocytotoxicity of the novel PEG-conjugated silicon(IV) phthalocyanine was also examined by testing against human cervical-carcinoma (HeLa) and hepato-carcinoma cells (HuH-7). The IC50 value for the SiPc-PEG compound was determined as 0.28 mu M for HeLa cells and 0.4 mu M for HuH-7 cells. These results imply that HeLa cells are apparently more responsive to photodynamic therapy (PDT) treatment by SiPc-PEG than HuH-7 cells at low concentrations (up to 0.5 mu M) of the studied photosensitizer. Additionally, SiPc-PEG showed antibacterial activity against Escherichia coli at 48 h of incubation, the viabilities of E. coli cultures exposed to 1000 mu g/mL and 2500 mu g/mL SiPc-PEG concentration were reduced by about 90%, and the additional growth inhibitory effect of photoactivation was also observed clearly at these efficient concentrations. To conclude, the novel compound may have a high potential for photodynamic therapy.tr_TR
dc.publisherWorld Sci Publ Co Inc, 27 Warren St, Ste 401-402, Hackensack, Nj 07601 USAtr_TR
dc.relationJournal of Porphyrins and Phthalocyaninestr_TR
dc.subjectPEG-conjugated silicon phthalocyaninetr_TR
dc.subjectantibacterial effecttr_TR
dc.subjectantitumoral activitytr_TR
dc.subjectphotodynamic therapytr_TR
dc.subjectHalogenated Silicon(Iv) Phthalocyaninestr_TR
dc.subjectPoly(Ethylene Glycol) Chainstr_TR
dc.subjectBovine Serum-Albumintr_TR
dc.subjectPhotochemical Propertiestr_TR
dc.subjectZinc Phthalocyaninestr_TR
dc.subjectPhotophysical Propertiestr_TR
dc.subjectMetal Phthalocyaninestr_TR
dc.titleA novel of PEG-conjugated phthalocyanine and evaluation of its photocytotoxicity and antibacterial properties for photodynamic therapytr_TR

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record