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dc.contributor.authorVurgun, Ufuk
dc.contributor.authorŞahin, Özlem
dc.contributor.authorTüfekçi, Kemal Uğur
dc.contributor.authorKeskinoğlu, Pembe
dc.contributor.authorYener, Görsev
dc.contributor.authorGenç, Kemal Kürşad
dc.contributor.authorGenç, Sermin
dc.date.accessioned2018-07-27T13:18:47Z
dc.date.available2018-07-27T13:18:47Z
dc.date.issued2013
dc.identifier.issn1304-2947
dc.identifier.urihttps://hdl.handle.net/11413/2388
dc.description.abstractIntroduction: Visfatin is a pleiotropic cytokine implicated in several physiological and pathophysiological processes such as innate immunity, cellular metabolism, longevity, and inflammation. Altered visfatin levels and visfatin gene polymorphisms have been reported in various human diseases, including type 2 diabetes mellitus, rheumatoid arthritis, obesity, coronary artery disease and stroke.. Materials and Method: In this study, we investigated whether serum visfatin levels were changed in volunteers with Alzheimer's disease (AD) (n = 40) or healthy controls (n=40) and whether visfatin gene G-948T polymorphism was associated with the disease. Results: Visfatin levels were not significantly different in AD patients compared with healthy aged control subjects. In this relatively small population, we found a significant, but weak association between GT heterozygous genotype at position -948 of visfatin gene and AD. However, there was no association between G-948T polymorphism and visfatin levels, and any demographic, anthropometric or biochemical parameters. Conclusion: Further studies in larger and different populations are needed to fully elaborate the involvement of visfatin gene in AD.tr_TR
dc.language.isoen_UStr_TR
dc.publisherGüneş Kitabevi Ltd Sti, M Rauf Inan Sok No 3, Ankara, Sıhhıye 06410, Turkeytr_TR
dc.relationTurkish Journal Of Geriatrics - Türk Geriatri Dergisitr_TR
dc.subjectNicotinamide Phosphoribosyltransferasetr_TR
dc.subjectAlzheimer Diseasetr_TR
dc.subjectPolymorphismtr_TR
dc.subjectInflammationtr_TR
dc.subjectAgingtr_TR
dc.subjectColony-Enhancing Factortr_TR
dc.subjectIschemic-Stroketr_TR
dc.subjectPlasma-Levelstr_TR
dc.subjectType-2tr_TR
dc.subjectObesetr_TR
dc.subjectInflammationtr_TR
dc.subjectPromotertr_TR
dc.titleAssociation Of Peripheral Visfatin Levels And Visfatin G-948T Gene Polymorphism With Alzheimer's Disease In A Turkish Populationtr_TR
dc.typeArticletr_TR
dc.contributor.authorID167754tr_TR
dc.contributor.authorID190994tr_TR
dc.contributor.authorID143760tr_TR
dc.contributor.authorID166828tr_TR
dc.contributor.authorID2453tr_TR


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