Browsing by Author "Çoker Gürkan, Ajda"
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Assessment of Interleukin-1 Gene Cluster Polymorphisms in Lone Atrial Fibrillation: New Insight into the Role of Inflammation in Atrial Fibrillation
Çoker Gürkan, Ajda; Güngör, Barış; Ekmekçi, Ahmet; Arman, Ahmet; Özcan, Kazım S.; Üçer, Ekrem; Çalık, Nazmi; Yılmaz, Hale; Tezel, Tuna; Bolca, Osman (Wiley-Blackwell, 111 River St, Hoboken 07030-5774, Nj USA, 2013-10)BackgroundSystemic inflammation is accepted as one of the pathophysiological mechanisms of atrial fibrillation (AF). The role of inflammation has been shown previously. Interleukin (IL) system is the main modulator of the ... -
Association between IL-1RN VNTR, IL-1 beta -511 and IL-6 (-174, -572, -597) Gene Polymorphisms and Urolithiasis
Çoker Gürkan, Ajda; Arısan, Elif Damla; Palavan Unsal, Narçin; Arısan, Serdar; Sonmez, Nurettin Cem (Karger, Allschwilerstrasse 10, Ch-4009 Basel, Switzerland, 2013)Urolithiasis is a common multifactorial urological disorder that is characterized by stone formation. Interleukin (IL)-1 and IL-6 are pro-inflammatory cytokines that might be linked with urolithiasis. The single nucleotide ... -
Autocrine Growth Hormone-Triggered Curcumin Resistance Abolished by NF-κB Signaling Pathway Dependent on Inflammatory Cytokines and Active Polyamine Catabolic Machinery in MCF-7, MDA-MB-453 and MDA-MB-231 Breast Cancer Cells
Çoker Gürkan, Ajda; Çelik, Merve; Uğur, Merve; Arısan, Elif Damla; Obakan Yerlikaya, Pınar; Ünsal, Zeynep Narçin (2017)Autocrine Growth Hormone (GH) induces cell growth, proliferation metastasis in breast cancer. Curcumin is a promising therapeutic agent in cancer through affecting different molecular targets. Our aim was to demonstrate ... -
Bag-1L is a Stress-withstand Molecule Prevents the Downregulation of Mcl-1 and c-Raf Under Control of Heat Shock Proteins in Cisplatin Treated HeLa Cervix Cancer Cells
Özfiliz Kılbaş, Pelin; Arısan, Elif Damla; Çoker Gürkan, Ajda; Obakan, Pınar; Eralp, Tuğçe Nur; Dinler Doğanay, Gizem; Palavan Unsal, Narçin (Asian Pacific Organization Cancer Prevention, Apjcp Head Office, Korean Natl Cancer Center, 323 Ilan -Ro, Ilsandong-Gu, Goyang-Si, Gyeonggi-Do, 410-769, South Korea, 2014)Background: Cisplatin, a DNA damaging agent, induces apoptosis through increasing DNA fragmentation. However, identification of intrinsic resistance molecules against Cisplatin is vital to estimate the success of therapy. ... -
Bag-1L mediated chemoresistance mechanism through preventing downregulation of Mcl-1 and c-Raf by heat shock proteins in HeLa cells
Eralp, Tuğçe Nur; Arısan, Elif Damla; Özfiliz, Pelin; Obakan Yerlikaya, Pınar; Çoker Gürkan, Ajda; Dinler Doğanay, Gizem; Ünsal, Zeynep Narçin (2014-11)Background: Cisplatin, a DNA damaging agent, induces apoptosis through increasing DNA fragmentation. However, identification of intrinsic resistance molecules against Cisplatin is vital to estimate the success of ... -
Calreticulin is a fine tuning molecule in epibrassinolide-induced apoptosis through activating endoplasmic reticulum stress in colon cancer cells
Obakan Yerlikaya, Pınar; Arısan, Elif Damla; Çoker Gürkan, Ajda; Adacan, Kaan; Özbey, Utku; Somuncu, Berna; Baran, Didem; Ünsal Palavan, Zeynep Narçın (Wiley, 111 River St, Hoboken 07030-5774, NJ USA, 2017-06)Epibrassinolide (EBR), a member of brassinostreoids plant hormones with cell proliferation promoting role in plants, is a natural polyhydroxysteroid with structural similarity to steroid hormones of vertebrates. EBR has ... -
Cathepsin K analysis in a pycnodysostosis cohort: demographic, genotypic and phenotypic features
Arman, Ahmet; Bereket, Abdullah; Çoker Gürkan, Ajda; Şimşek Kiper, Pelin Özlem; Güran, Tülay; Özkan, Behzat; Atay, Zeynep; Akçay, Teoman; Haliloğlu, Belma; Boduroğlu, Koray; Alanay, Yasemin; Turan, Serap (Biomed Central Ltd, 236 Grays Inn Rd, Floor 6, London Wc1X 8Hl, England, 2014-04-26)Background: To characterize cathepsin K (CTSK) mutations in a group of patients with pycnodysostosis, who presented with either short stature or atypical fractures to pediatric endocrinology or dysmorphic features to ... -
CDK Inhibitors Induce Mitochondria-mediated Apoptosis Through the Activation of Polyamine Catabolic Pathway in LNCaP, DU145 and PC3 Prostate Cancer Cells
Arısan, Elif Damla; Obakan, Pınar; Çoker Gürkan, Ajda; Calcabrini, Annarica; Agostinelli, Enzo; Palavan Unsal, Narçin (Bentham Science Publ Ltd, Executive Ste Y-2, Po Box 7917, Saif Zone, 1200 Br Sharjah, U Arab Emirates, 2014-01)Androgen signaling is critical in prostate cancer development and progression. The co-existence of hormone responsive and irresponsive cells due to functional androgen receptor (AR) in prostate gland is the major obstacle ... -
CDK inhibitors-induced SSAT expression requires NF kappa B and PPAR gamma in MCF-7 breast cancer cells
Obakan Yerlikaya, Pınar; Yıldırım, Şeyma; Öztürk, Mert Burak; Berrak, Özge; Çoker Gürkan, Ajda; Arısan, Elif Damla; Ünsal Palavan, Zeynep Narçın (TUBİTAK Scientific & Technical Research Council Turkey, Ataturk Bulvarı No 221, Kavaklıdere, Ankara, 00000, Turkey, 2015)The cyclin-dependent kinase (CDK) inhibitors purvalanol and roscovitine are therapeutic agents that control cell proliferation through regulating cell-cycle machinery. They also affect polyamine (PA) metabolism, which is ... -
Celastrol Modulates Lipid Synthesis via PI3K/Akt/mTOR Signaling Axis to finalize Cell Death Response in Prostate Cancer Cells
Arısan, Elif Damla; Rencüzoğulları, Özge; Çoker Gürkan, Ajda; Obakan Yerlikaya, Pınar; Ünsal, Zeynep Narçin (2017)FASN is key enzyme during lipid biogenesis is associated with prostate cancer. In this study, we aim to investigate the potential role of celastrol, root extracts of Tripterygium wilfordii on modulation of lipid ... -
Combined Treatment of Roscovitine and DFMO Induced Caspase Dependent Apoptosis in MCF-7 cells. 2nd
Obakan Yerlikaya, Pınar; Arısan, Elif Damla; Ünsal, Zeynep Narçin; Çoker Gürkan, Ajda (2010) -
Cox-2 inhibitor ibuprofen induced apoptosis via altering different signalling routes in HT-29 and DLD-1 colon cancer cells
Yalçın, Gizem Damla; Arısan, Elif Damla; Çoker Gürkan, Ajda; Obakan Yerlikaya, Pınar; Ünsal, Zeynep Narçin (2015) -
Curcumin induced-apoptotic cell death in GH overexpressed MDA-MB-231 breast cancer in time dependent manner
Çelik, Merve; Çoker Gürkan, Ajda; Arısan, Elif Damla; Obakan Yerlikaya, Pınar; Ünsal, Zeynep Narçin (2015) -
Curcumin induced-apoptotic cell death in GH overexpressed MDA-MB-231 breast cancer in time dependent manner
Çelik, Merve; Çoker Gürkan, Ajda; Arısan, Elif Damla; Yerlikaya, Pınar Obakan; Palavan Ünsal, Zeynep Narçın (Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ USA, 2015-07) -
Curcumin inhibits autocrine growth hormone-mediated invasion and metastasis by targeting NF-kappa B signaling and polyamine metabolism in breast cancer cells
Çoker Gürkan, Ajda; Çelik, Merve; Uğur, Merve; Arısan, Elif Damla; Obakan Yerlikaya, Pınar; Durdu, Zeynep Begüm; Ünsal Palavan, Zeynep Narçın (2018-08)Curcumin is assumed to be a plant-derived therapeutic drug that triggers apoptotic cell death in vitro and in vivo by affecting different molecular targets such as NF-kappa B. Phase I/II trial of curcumin alone or with ... -
Curcumin Prevented Human Autocrine Growth Hormone (GH) Signaling Mediated NF-κB Activation and miR-183-96-182 Cluster Stimulated Epithelial Mesenchymal Transition in T47D Breast Cancer Cells
Obakan Yerlikaya, Pınar; Çoker Gürkan, Ajda; Bulut, Derya; Genç, Recep; Arısan, Elif Damla; Ünsal, Zeynep Narçin; Palavan-Unsal, Narcin (2019-02)Autocrine growth hormone (GH) signaling is a promoting factor for breast cancer via triggering abnormal cell growth, proliferation, and metastasis, drug resistance. Curcumin (diferuloylmethane), a polyphenol derived from ... -
Cyclin Dependent Kinase Inhibitors Modulates Polyamine Metabolism in MDA-MB-231 Cells
Ünsal, Zeynep Narçin; Arısan, Elif Damla; Obakan Yerlikaya, Pınar; Çoker Gürkan, Ajda; Özdemir, İpek (2010) -
Cyclin-dependent kinase inhibitors, roscovitine and purvalanol, induce apoptosis and autophagy related to unfolded protein response in HeLa cervical cancer cells
Özfiliz Kılbaş, Pelin; Sarıkaya, Bahar; Obakan Yerlikaya, Pınar; Çoker Gürkan, Ajda; Arısan, Elif Damla; Temizci, Benan; Palavan Ünsal, Zeynep Narçın (Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands, 2018-10)Roscovitine (Rosc) and purvalanol (Pur) are competitive inhibitors of cyclin-dependent kinases (CDKs) by targeting their ATP-binding pockets. Both drugs are shown to be effective to decrease cell viability and dysregulate ... -
Cytokine network is critical in growth hormone-induced resistance mechanism against curcumin which modulates JAK/STAT/SOCS pathway in MDA-MB-231 and MCF-7 breast cancer cells
Çelik, Merve; Çoker Gürkan, Ajda; Arısan, Elif Damla; Obakan Yerlikaya, Pınar; Ünsal, Zeynep Narçin (2016) -
Cytokine network is critical in growth hormone-induced resistance mechanism against curcumin which modulates JAK/STAT/SOCS pathway in MDA-MB-231 and MCF-7 breast cancer cells
Çelik, Merve; Çoker Gürkan, Ajda; Arısan, Elif Damla; Obakan Yerlikaya, Pınar; Palavan Ünsal, Zeynep Narçın (Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ USA, 2016-09)