Browsing by Author "Arısan, Elif Damla"
Now showing items 1-20 of 129
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24-Epibrassinolide Induces SSAT and Causes Caspase-Dependent Apoptosis In Different Prostate Cancer Cell Lines
Obakan Yerlikaya, Pınar; Arısan, Elif Damla; Bolkent, Şehnaz; Ünsal, Zeynep Narçin (2011) -
Activation of polyamine catabolic enzymes involved in diverse responses against epibrassinolide-induced apoptosis in LNCaP and DU145 prostate cancer cell lines
Obakan, Pınar; Arısan, Elif Damla; Palavan Unsal, Narçin; Calcabrini, Annarica; Agostinelli, Enzo; Bolkent, Şehnaz (Springer Wien, Sachsenplatz 4-6, Po Box 89, A-1201 Wien, Austria, 2014-03)Epibrassinolide (EBR) is a biologically active compound of the brassinosteroids, steroid-derived plant growth regulator family. Generally, brassinosteroids are known for their cell expansion and cell division-promoting ... -
Antioxidant enzyme profile in chronic pelvic pain syndrome patients
Arısan, Elif Damla; Arısan, Serdar; Kiremit, Murat Can; Palavan-Ünsal, Narçin; Ergenekon, Erbil (İstanbul Kültür Üniversitesi Yayınları, 2007-03)Chronic pelvic pain syndrome (CPPS) is a common and serious health problem affecting the quality of life in men. According to National Institute of Health classification system abacterial chronic pelvic pain has two ... -
Association between IL-1RN VNTR, IL-1 beta -511 and IL-6 (-174, -572, -597) Gene Polymorphisms and Urolithiasis
Çoker Gürkan, Ajda; Arısan, Elif Damla; Palavan Unsal, Narçin; Arısan, Serdar; Sonmez, Nurettin Cem (Karger, Allschwilerstrasse 10, Ch-4009 Basel, Switzerland, 2013)Urolithiasis is a common multifactorial urological disorder that is characterized by stone formation. Interleukin (IL)-1 and IL-6 are pro-inflammatory cytokines that might be linked with urolithiasis. The single nucleotide ... -
Autocrine Growth Hormone-Triggered Curcumin Resistance Abolished by NF-κB Signaling Pathway Dependent on Inflammatory Cytokines and Active Polyamine Catabolic Machinery in MCF-7, MDA-MB-453 and MDA-MB-231 Breast Cancer Cells
Çoker Gürkan, Ajda; Çelik, Merve; Uğur, Merve; Arısan, Elif Damla; Obakan Yerlikaya, Pınar; Ünsal, Zeynep Narçin (2017)Autocrine Growth Hormone (GH) induces cell growth, proliferation metastasis in breast cancer. Curcumin is a promising therapeutic agent in cancer through affecting different molecular targets. Our aim was to demonstrate ... -
Bag-1 promotes cell survival through c-Myc-mediated ODC upregulation that is not preferred under apoptotic stimuli in MCF-7 cells
Özfiliz Kılbaş, Pelin; Kızılboğa, Tuğba; Demir, Salih; Palavan Ünsal, Zeynep Narçın; Arısan, Elif Damla; Dinler Doğanay, Gizem (Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ USA, 2015-07)Bag-1, Bcl-2 associated athanogene-1, is a multifunctional protein that can regulate a wide variety of cellular processes: proliferation, cell survival, transcription, apoptosis and motility. Bag-1 interacts with various ... -
Bag-1 silencing enhanced apoptosis via altering the ubiquitination process of Foxo3a in MCP-7 breast cancer cells
Özfiliz Kılbaş, Pelin; Arısan, Elif Damla; Dinler Doğanay, Gizem; Palavan Ünsal, Zeynep Narçın (Spandidos Publ Ltd, Pob 18179, Athens, 116 10, Greece, 2017) -
Bag-1 Silencing Enhanced Chemotherapeutic Drug-induced Apoptosis in MCF-7 Breast Cancer Cells Affecting PI3K/Akt/mTOR and MAPK Signaling Pathways
Özfiliz Kılbaş, Pelin; Akçay, İzzet Mehmet; Dinler Doğanay, Gizem; Arısan, Elif Damla (2019-01-19)The multifunctional anti-apoptotic Bag-1 protein has important roles in apoptosis, proteasome-mediated degradation, transcriptional regulation, and intracellular signaling. Bag-1 promotes cell survival and proliferation, ... -
Bag-1L is a Stress-withstand Molecule Prevents the Downregulation of Mcl-1 and c-Raf Under Control of Heat Shock Proteins in Cisplatin Treated HeLa Cervix Cancer Cells
Özfiliz Kılbaş, Pelin; Arısan, Elif Damla; Çoker Gürkan, Ajda; Obakan, Pınar; Eralp, Tuğçe Nur; Dinler Doğanay, Gizem; Palavan Unsal, Narçin (Asian Pacific Organization Cancer Prevention, Apjcp Head Office, Korean Natl Cancer Center, 323 Ilan -Ro, Ilsandong-Gu, Goyang-Si, Gyeonggi-Do, 410-769, South Korea, 2014)Background: Cisplatin, a DNA damaging agent, induces apoptosis through increasing DNA fragmentation. However, identification of intrinsic resistance molecules against Cisplatin is vital to estimate the success of therapy. ... -
Bag-1L mediated chemoresistance mechanism through preventing downregulation of Mcl-1 and c-Raf by heat shock proteins in HeLa cells
Eralp, Tuğçe Nur; Arısan, Elif Damla; Özfiliz, Pelin; Obakan Yerlikaya, Pınar; Çoker Gürkan, Ajda; Dinler Doğanay, Gizem; Ünsal, Zeynep Narçin (2014-11)Background: Cisplatin, a DNA damaging agent, induces apoptosis through increasing DNA fragmentation. However, identification of intrinsic resistance molecules against Cisplatin is vital to estimate the success of ... -
Biological responses of ultrafine grained pure titanium and their sand blasted surfaces
Günay Bulutsuz, Aslı; Berrak, Özge; Yeprem, H. Aygül; Arısan, Elif Damla; Yurci, Mehmet Emin (Elsevier Science Bv, Po Box 211, 1000 Ae Amsterdam, Netherlands, 2018-10-01)The use of materials as implants has become vital for determining optimal product design to enhance the needs of usage and longevity in body. Ultrafine grained pure titanium offers advanced mechanical properties for medical ... -
Calreticulin is a fine tuning molecule in epibrassinolide-induced apoptosis through activating endoplasmic reticulum stress in colon cancer cells
Obakan Yerlikaya, Pınar; Arısan, Elif Damla; Çoker Gürkan, Ajda; Adacan, Kaan; Özbey, Utku; Somuncu, Berna; Baran, Didem; Ünsal Palavan, Zeynep Narçın (Wiley, 111 River St, Hoboken 07030-5774, NJ USA, 2017-06)Epibrassinolide (EBR), a member of brassinostreoids plant hormones with cell proliferation promoting role in plants, is a natural polyhydroxysteroid with structural similarity to steroid hormones of vertebrates. EBR has ... -
CDK Inhibitors Induce Mitochondria-mediated Apoptosis Through the Activation of Polyamine Catabolic Pathway in LNCaP, DU145 and PC3 Prostate Cancer Cells
Arısan, Elif Damla; Obakan, Pınar; Çoker Gürkan, Ajda; Calcabrini, Annarica; Agostinelli, Enzo; Palavan Unsal, Narçin (Bentham Science Publ Ltd, Executive Ste Y-2, Po Box 7917, Saif Zone, 1200 Br Sharjah, U Arab Emirates, 2014-01)Androgen signaling is critical in prostate cancer development and progression. The co-existence of hormone responsive and irresponsive cells due to functional androgen receptor (AR) in prostate gland is the major obstacle ... -
CDK inhibitors-induced SSAT expression requires NF kappa B and PPAR gamma in MCF-7 breast cancer cells
Obakan Yerlikaya, Pınar; Yıldırım, Şeyma; Öztürk, Mert Burak; Berrak, Özge; Çoker Gürkan, Ajda; Arısan, Elif Damla; Ünsal Palavan, Zeynep Narçın (TUBİTAK Scientific & Technical Research Council Turkey, Ataturk Bulvarı No 221, Kavaklıdere, Ankara, 00000, Turkey, 2015)The cyclin-dependent kinase (CDK) inhibitors purvalanol and roscovitine are therapeutic agents that control cell proliferation through regulating cell-cycle machinery. They also affect polyamine (PA) metabolism, which is ... -
Celastrol Modulates Lipid Synthesis via PI3K/Akt/mTOR Signaling Axis to finalize Cell Death Response in Prostate Cancer Cells
Arısan, Elif Damla; Rencüzoğulları, Özge; Çoker Gürkan, Ajda; Obakan Yerlikaya, Pınar; Ünsal, Zeynep Narçin (2017)FASN is key enzyme during lipid biogenesis is associated with prostate cancer. In this study, we aim to investigate the potential role of celastrol, root extracts of Tripterygium wilfordii on modulation of lipid ... -
Cisplatin overcomes Bcl-2-mediated resistance to apoptosis via preferential engagement of Bak: critical role of Noxa-mediated lipid peroxidation
Kütük, Özgür; Arısan, Elif Damla; Tezil, Tuğsan; Shoshan, Maria C.; Başağa, Hüveyda (Oxford University Press, 2009-09-01)Increased expression of antiapoptotic Bcl-2 proteins confers therapeutic resistance in various cancer types. Targeting Bcl-2 proteins by small molecules or activating alternative pathways to bypass Bcl-2-mediated protection ... -
Combined Treatment of Roscovitine and DFMO Induced Caspase Dependent Apoptosis in MCF-7 cells. 2nd
Obakan Yerlikaya, Pınar; Arısan, Elif Damla; Ünsal, Zeynep Narçin; Çoker Gürkan, Ajda (2010) -
Comparison of the effect of different cytokinins on chlorophyll, protein content and peroxidase activity
Ünsal, Zeynep Narçin; Çağ, Serap; Arısan, Elif Damla (2001) -
Comparison of the effects of meta-topolin and other cytokinins on chlorophyll and protein contents and peroxidase activity in cucumber cotyledons
Çağ, Serap; Arısan, Elif Damla; Ünsal, Zeynep Narçin; Arısan, Elif Damla (Taylor and Francis Online, 2003)Cytokinins play an important role in controlling many of the processes that contribute to plant senescence. The aim of this study was to compare the effect of different cytokinins, especially the new aromatic cytokinin ... -
Cox-2 inhibitor ibuprofen induced apoptosis via altering different signalling routes in HT-29 and DLD-1 colon cancer cells
Yalçın, Gizem Damla; Arısan, Elif Damla; Çoker Gürkan, Ajda; Obakan Yerlikaya, Pınar; Ünsal, Zeynep Narçin (2015)