Browsing by Author "Coşkun, Deniz"
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Diclofenac induced apoptosis via altering PI3K/Akt/MAPK signaling axis in HCT 116 more efficiently compared to SW480 colon cancer cells
Arısan, Elif Damla; Ergül, Zehragül; Bozdağ, Gülnihal; Rencüzoğulları, Özge; Çoker Gürkan, Ajda; Obakan Yerlikaya, Pınar; Coşkun, Deniz; Ünsal, Zeynep Narçin (Springer Link, 2018-12)Diclofenac is a preferential cyclooxygenase 2 inhibitor (COX-2) and member of non-steroidal anti-inflammatory drugs (NSAIDs). Inflammation is one of the main reason of poor prognosis of colon cancer cases; thereby NSAIDs ... -
Downregulation of c-Myc mediated ODC expression after purvalanol treatment is under control of upstream MAPK signaling axis in MCF-7 breast cancer cells
Obakan, Pınar; Alkurt, Gizem; Köse, Betsi; Çoker Gürkan, Ajda; Arısan, Elif Damla; Coşkun, Deniz; Palavan Unsal, Narçin (Tubitak Scientific & Technical Research Council Turkey, Ataturk Bulvarı No 221, Kavaklıdere, Ankara, 00000, Turkey, 2014)Roscovitine and purvalanol are specific cyclin-dependent kinase (CDK) inhibitors, which induce apoptosis by triggering cell cycle arrest in various cancer cells such as colon, prostate, and breast cancer cells. Although ... -
Epibrassinolide alters PI3K/MAPK signaling axis via activating Foxo3a-induced mitochondria-mediated apoptosis in colon cancer cells
Coşkun, Deniz; Obakan Yerlikaya, Pınar; Arısan, Elif Damla; Çoker Gürkan, Ajda; Palavan Unsal, Narcin (Elsevier Inc, 525 B Street, Ste 1900, San Diego, Ca 92101-4495 Usa, 2015-10-15)Epibrassinolide (EBR), a steroid-derived plant growth regulator, has been recently suggested as an apoptotic inducer in different cancer cells. In this experimental study, we investigated the potential apoptotic effect of ... -
Epibrassinolide-induced Apoptosis is Modulated by AKT-FOXO3a Signaling Pathway
Coşkun, Deniz; Obakan Yerlikaya, Pınar; Arısan, Elif Damla; Çoker Gürkan, Ajda; Ünsal, Zeynep Narçin (2014) -
Fetuin-A 742 (C/T) and 766 (C/G) polymorphic sites are associated with increased risk of myocardial infarction in older patients (40 years of age)
Çoker Gürkan, Ajda; Coşkun, Deniz; Arısan, Elif Damla; Obakan Yerlikaya, Pınar; Palavan Ünsal, Zeynep Narçın (Spandidos Publ Ltd, Pob 18179, Athens, 116 10, Greece, 2015-07)Inflammation and genetics have key roles in the pathogenesis of atherosclerosis, and the etiology of myocardial infarction (MI). Recent studies have indicated that lower serum levels of fetuin-A may accelerate the vascular ... -
HCT 116 ve HT 29 kolon karsinoma hücrelerinde epibrassinolid tarafından tetiklenen apoptotik süreçte poliaminlerin rolü
Coşkun, Deniz (İstanbul Kültür Üniversitesi / Fen Bilimleri Enstitüsü / Moleküler Biyoloji ve Genetik Anabilim Dalı, 2014-01)Kolon kanseri gastrointestinal sistemde meydana gelen, kanserden ölümlerde akciğer kanserinden sonra gelen yaygın bir kanser türüdür. Kötü beslenme, hareketsiz yaşam tarzı ve sigara kullanımı gibi farklı çevresel etkenlerle ... -
NSAIDs, ibuprofen and diclofenac induced apoptosis via altering MAPKs and de novo protein synthesis regardless of COX-2 expression in SW480 colon cancer cells
Bozdağ, Gülnihal; Arısan, Elif Damla; Obakan Yerlikaya, Pınar; Çoker Gürkan, Ajda; Coşkun, Deniz; Ünsal, Zeynep Narçin (2015)