Browsing by Author "Köse, Betsi"
Downregulation of c-Myc mediated ODC expression after purvalanol treatment is under control of upstream MAPK signaling axis in MCF-7 breast cancer cells Obakan, Pınar; Alkurt, Gizem; Köse, Betsi; Çoker Gürkan, Ajda; Arısan, Elif Damla; Coşkun, Deniz; Palavan Unsal, Narçin (Tubitak Scientific & Technical Research Council Turkey, Ataturk Bulvarı No 221, Kavaklıdere, Ankara, 00000, Turkey, 2014)Roscovitine and purvalanol are specific cyclin-dependent kinase (CDK) inhibitors, which induce apoptosis by triggering cell cycle arrest in various cancer cells such as colon, prostate, and breast cancer cells. Although ...
ODC is a Mediator of the Purvalanol A-Induced Apoptotic Signaling via the p38 Mitogen-Activated Protein Kinase Pathway in MCF-7 Breast Cancer Cells Köse, Betsi; Alkurt, Gizem; Çoker Gürkan, Ajda; Arısan, Elif Damla; Ünsal, Zeynep Narçin (2012)
Çoker Gürkan, Ajda; Arısan, Elif Damla; Obakan Yerlikaya, Pınar; Özfiliz Kılbaş, Pelin; Köse, Betsi; Bıçkıcı, Güven; Palavan Ünsal, Zeynep Narçın (Spandidos Publ Ltd, Pob 18179, Athens, 116 10, Greece, 2015-03)The cell cycle is tightly regulated by the family of cyclin-dependent kinases (CDKs). CDKs act as regulatory factors on serine and threonine residues by phosphorylating their substrates and cyclins. CDK-targeting drugs ...