Now showing items 1-2 of 2

    • Calpain inhibitor AK 295 inhibits calpain-induced apoptosis and improves neurologic function after traumatic spinal cord injury in rats 

      Çolak, Ahmet; Kaya, Mehmet; Karaoğlan, Alper; Sağmanlıgil, Ayhan; Akdemir, Osman; Şahan, Elife; Çelik, Özge (Soc Espanola Neurocirugia, C/O Dr Poza, Gran Via Salzillo 42, 30005 Murcia, Spain, 2009-06)
      Background. An increase in the level of intracellular calcium activates the calcium-dependent neutral protease calpain, which in turn leads to cellular dysfunction and cell death after an insult to the central nervous ...
    • Tauroursodeoxycholic acid and secondary damage after spinal cord injury in rats 

      Çolak, Ahmet; Kelten, Bilal; Sağmanlıgil, Ayhan; Akdemir, Osman; Karaoğlan, Alper; Şahan, Elife; Çelik, Özge; Barut, Şeref (CHURCHILL LIVINGSTONE, JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND, 2008-06)
      Greater clinical understanding of the pivotal role of apoptosis in spinal cord injury (SCI) has led to new and innovative apoptosisbased therapies for patients with an SCL Tauroursodeoxycholic acid (TUDCA) is a biliary ...