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  • Publication
    Translation and Validation of the ELPO for Turkish Population: Risk Assessment Scale for the Development of Pressure Injuries Due to Surgical Positioning
    (Elsevier, 2022) Şengül, Tuğba; GÜL, ASİYE; Yılmaz, Dilek; Gökduman, Tuğba
    Aim of the study: This study was conducted to translate the ELPO risk assessment scale for the development of pressure injuries due to surgical positioning to Turkish and to test its validity and reliability in the Turkish Population. Materials and methods: The data were collected using the patient identification form, the risk assessment scale for the prevention of injuries due to surgical positioning, and the Braden Scale. This scale consisted of a total of seven items, each of which contained five sub-items. It is rated between 1 and 5 in the Likert type. The total score of the scale ranges between 7 and 35. The risk of developing pressure injuries increases in patients as the score increases. Results: A total of 184 patients were included in the study sample. The mean age of the group was 55.96 ± 17.90, and the content validity index was 0.944. The sensitivity of the test was 60%, the specificity was 66%, and the accuracy was 66%. There was a negative, weak, statistically significant correlation between the total scores of the risk assessment scale for the prevention of injuries due to surgical positioning and the Braden scale. The mean total score of the scale was 18.45 ± 2.96 (12-26) and 35.9% (n = 66) of the group were at high risk. Conclusions: The ELPO, which includes the risks specific to patients during surgery, can be used as an assessment scale for the development of pressure injury due to surgical positioning for Turkish population.
  • Publication
    The Determination of Patient Learning Needs After Day Surgery: A Cross-Sectional Study
    (Elsevier, 2022) Üstündağ, Hülya; GÜL, ASİYE; Özkaya, Birgül
    Purpose: This study was conducted to investigate the care perception and learning needs of patients undergoing day surgery. Design: A descriptive and cross-sectional model was used. Methods: The study was conducted with 234 patients who underwent day surgery in a general surgery clinic of a university hospital. Data were collected using a sociodemographic characteristics form, the Patient Perception of Hospital Experience with Nursing Scale (PPHEN) and the Patient Learning Needs Scale (PLNS). Findings: The PPHEN mean score was 67.99 ± 11.98 and the PLNS total score was 211.15 ± 38.49. The subscales showed that the highest scores were 38.47 ± 6.93 for activities of life, while the lowest score was 20.60 ± 4.23 for feelings related to condition. There was a statistically significant negative correlation in the PPHEN and PLNS subscales in terms of medications, activities of living, treatment, and complications. There was no statistically significant relationship between the demographic data of the patients (age, gender, and educational status). Conclusions: This study demonstrated that patients had high information needs and greater concerns, particularly about "activities of life." Nurses should be aware of the importance of identifying high learning needs to increase the level of satisfaction with nursing care in day surgery patients.
  • Publication
    Open Access
    CRISPR/Cas9-Mediated Bag-1 Knockout Increased Mesenchymal Characteristics of MCF-7 Cells Via Akt Hyperactivation-Mediated Actin Cytoskeleton Remodeling
    (Public Library of Science, 2022) KILBAŞ, PELİN ÖZFİLİZ; Can, Nisan Denizce; Kızılboğa, Tuğba; Ezberci, Fikret; Doğanay, Hamdi Levent; Arışan, Elif Damla; Doğanay, Gizem Dinler
    Bag-1 protein is a crucial target in cancer to increase the survival and proliferation of cells. The Bag-1 expression is significantly upregulated in primary and metastatic cancer patients compared to normal breast tissue. Overexpression of Bag-1 decreases the efficiency of conventional chemotherapeutic drugs, whereas Bag-1 silencing enhances the apoptotic efficiency of therapeutics, mostly in hormone-positive breast cancer subtypes. In this study, we generated stable Bag-1 knockout (KO) MCF-7 breast cancer cells to monitor stress-mediated cellular alterations in comparison to wild type (wt) and Bag-1 overexpressing (Bag-1 OE) MCF-7 cells. Validation and characterization studies of Bag-1 KO cells showed different cellular morphology with hyperactive Akt signaling, which caused stress-mediated actin reorganization, focal adhesion decrease and led to mesenchymal characteristics in MCF-7 cells. A potent Akt inhibitor, MK-2206, suppressed mesenchymal transition in Bag-1 KO cells. Similar results were obtained following the recovery of Bag-1 isoforms (Bag-1S, M, or L) in Bag-1 KO cells. The findings of this study emphasized that Bag-1 is a mediator of actin-mediated cytoskeleton organization through regulating Akt activation. © 2022 Kilbas et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
  • Publication
    Effect of the Head of Bed Elevation on Back Pain After Elective Coronary Angiography: A Randomized Controlled Trial
    (W.B. Saunders, 2022) TÜREN, SEVDA; YILMAZ, RAHİME ATAKOĞLU; Yeşiltepe, Nezahat; Bektaş, İbrahim
    Background: Patients are restricted to bed and required to lie flat after coronary angiography (CAG) due to potential risk of vascular complications. This often cause back pain. Aim: We aimed to investigate effect of the head of bed (HOB) elevation on back pain and vascular complications after elective CAG. Methods: Three hundred and seven consecutive patients who underwent elective CAG were randomized into three groups. One control (HOB: 0 degree-flat position) and two experimental (HOB: 15 and 30°) groups were compared. Back pain level was assessed by using visual analogue scale. Results: Mean age was 58.1 ± 10.7 and 59.9% (n = 184) of patients were male. Pain level at the 3rd hour and at the 6th hour was significantly higher in control group compared to experimental groups. In the post-hoc analysis, pain level was significantly higher in HOB 15 compared to 30°. In multivariate analysis, HOB elevation to 30° was the only independent predictor of the pain level at 3rd hour and 6th hour. Only one patient in the HOB 0 degree group had a minor bleeding at the access site. Conclusions: Elevation of the HOB to 30° was associated with decreased back pain level without increased risk of vascular complications. © 2022 Elsevier Inc.