Publication:
Molecular Mechanics Studies of Antihypertensive Val-Tyr Dipeptide

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Date
2010-01
Authors
Akverdieva, G. A.
Godjayev, N. M.
Akyüz, Sevim
Akyüz, Tanıl
Doğan, N. E.
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Publisher
Asian Journal Of Chemistry, 11/100 Rajendra Nagar, Sector 3,, Sahibabad 201 005, Ghaziabad, India
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Abstract

The spatial structure of anti hypertensive dipeptide,Valine-Tyrosine was investigated within molecular mechanics framework. It ha, been shown that the molecule has such a structural organization which does not exclude the realization of two types of conformation: folded and extended. The energy and geometrical parameters for the optimal conformations of dipeptide are obtained. The electronic characteristics for these structures were analyzed by quantum chemical calculations.

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Keywords
Antihypertensive peptide , Conformational analysis , Molecular mechanics , Tyrosine , Valine , peptide , antihipertansif peptid , konformasyonal analizi , moleküler mekanik , tirozin , peptid
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