Association between IL-1RN VNTR, IL-1 beta -511 and IL-6 (-174, -572, -597) Gene Polymorphisms and Urolithiasis

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Çoker Gürkan, Ajda
Arısan, Elif Damla
Palavan Unsal, Narçin
Arısan, Serdar
Sonmez, Nurettin Cem
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Karger, Allschwilerstrasse 10, Ch-4009 Basel, Switzerland
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Urolithiasis is a common multifactorial urological disorder that is characterized by stone formation. Interleukin (IL)-1 and IL-6 are pro-inflammatory cytokines that might be linked with urolithiasis. The single nucleotide polymorphisms within the IL-1 and IL-6 cytokine genes altered the cytokine expression levels. Our aim was to investigate the potential of IL-1 beta (-511 C>T), IL-6 (-174 G>C, 572 G>C, 597 G>A) and IL-1 RN VNTR gene polymorphisms to be a genetic marker for urinary stone disease. The polymorphisms studied in the promoter regions of IL-1 beta and IL-6 genes did not reveal a strong association with urolithiasis when compared to the control group (p = 0.293, 0.871, 0.921, 0.536, respectively). However, a significant difference was observed between control and patient groups for IL-1 RN VNTR gene polymorphism (chi(2) = 6.131, d.f. = 2, p = 0.047). Our data provide evidence that IL-1RN VNTR gene polymorphism may be involved in the pathogenesis of urinary stone formation, contributing to genetic susceptibility for urolithiasis. (C) 2013 S. Karger AG, Basel

Urolithiasis , Interleukin-1 , Interleukin-6 , Single nucleotide polymorphism , Receptor Antagonist Gene , Calcium-Oxalate Stones , Vitamin-D-Receptor , Kidney-Stones , Interleukin-1-Beta Gene , Tandem Repeat , Nephrolithiasis , Excretion , Intron-2 , Protein