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Purvalanol induces endoplasmic reticulum stress mediated apoptosis and autophagy by purvalanol in HCT 116 colon cancer cells
Purvalanol, a novel cyclin-dependent kinase inhibitor, is referred to as a strong apoptotic inducer which causes cell cycle arrest in various cancer cells such as prostate, breast and colon cancer cell lines. Various ...
Roscovitine treatment inhibited cell proliferation and induced apoptosis via modulating activity of Stat3 and Foxo1 under control of Akt in LNCaP prostate cancer cells
Cyclin dependent kinases (CDKs) are known activators of nuclear hormone receptors; such as androgen receptor (AR) via modulating several cell survival signaling routes. However, novel CDK inhibitors might also prevent cell ...
Epibrassinolide Induced Apoptosis via Endoplasmic Reticulum Stress Regardless of p53 Expression in Prostate Cancer Cells
Epibrassinolide (EBR) is a member of brassinosteroids a class of plant polyhydroxysteroids, with well-known growth-promoting roles. EBR induces apoptosis in prostate cancer cells both LNCaP expressing functional androgen ...