Now showing items 1-10 of 15
Orlistat is a fatty acid synthase (FASN) inhibitor caused the modulation of AMPK and lipogenesis signaling axis in PC3 prostate cancer cells but not in PNT1A prostate epithelial cells
Prostate cancer is one the leading cancer type after lung cancer among male. Obesity is one of the known risk factor for developing highly aggressive and metastatic prostate cancer, which is an obstacle in cancer therapy. ...
Epibrassinolide Treatment Caused Autophagy or Apoptosis Decision in a Time-Dependent Manner through ER Stress in Colon Cancer Cells
Epibrassinolide (EBR) is a natural plant polyhydroxysteroid with structural similarity to steroid hormones. Lately we showed by SILAC assay that EBR treatment induces apoptosis by significantly altering the expressions of ...
Celastrol Modulates Lipid Synthesis via PI3K/Akt/mTOR Signaling Axis to finalize Cell Death Response in Prostate Cancer Cells
FASN is key enzyme during lipid biogenesis is associated with prostate cancer. In this study, we aim to investigate the potential role of celastrol, root extracts of Tripterygium wilfordii on modulation of lipid ...
Autocrine Growth Hormone-Triggered Curcumin Resistance Abolished by NF-κB Signaling Pathway Dependent on Inflammatory Cytokines and Active Polyamine Catabolic Machinery in MCF-7, MDA-MB-453 and MDA-MB-231 Breast Cancer Cells
Autocrine Growth Hormone (GH) induces cell growth, proliferation metastasis in breast cancer. Curcumin is a promising therapeutic agent in cancer through affecting different molecular targets. Our aim was to demonstrate ...
Endoplasmic reticulum stress is activated after epibrassinolide treatment leading autophagy in wild type and Atg5/ mouse embryonic fibroblasts: a survival mechanism in nonmalignant cells.
Autophagy is a process of cellular selfdegradation during which macromolecules, damaged/aged organelles and proteins are delivered to the lysosome by engulfment within doublemembrane vesicles. The accumulation of ...