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Event Related Oscillations in Euthymic Patients With Bipolar Disorder

Thumbnail
Author
Özerdem, Ayşegül
Kocaaslan, Sibel
Tunca, Zeliha
Başar, Erol
Type
Article
Date
2008-10-17
Language
en_US
Metadata
Show full item record
Abstract
Bipolar disorder involves dysfunction in gamma amino butyric acid (GABA)/glutamatergic systems and neural circuits that regulate cognitive processing. Valproate, a mood stabilizing anticonvulsant, modulates GABA/glutamate and shows neuroprotective effect. Electroencephalographic oscillatory activity assessment is an alternative brain imaging technique with high time resolution. It presents integrative brain functioning. We aimed to assess the oscillatory responses of patients with bipolar disorder in euthymic state of bipolar disorder and the changes after treatment with valproate. Event related potentials to visual odd-ball paradigm in 10 euthymic medication free, bipolar patients were measured before and after 6 weeks of valproate monotherapy and compared with sex- and age-matched healthy controls. Delta frequency bands, as representative of signal detection and decision-making, were obtained by digital filtering. At baseline, patients showed higher delta responses to target stimuli in all but significantly left frontal channels in comparison to controls. After 6 weeks of treatment, delta responses decreased significantly in central frontal (Fz) (p: 0.028), left frontal (F3) (p: 0.028), left (T3) (p: 0.015), right anterior (T4) (p: 0.011), and left posterior temporal (T5) (p: 0.011) channels compared to baseline and became no different to the controls, which did not differ between two assessments. The findings point to a diffuse increase in low frequency electrical activity which was prominent in the left frontal location in euthymic patients with bipolar disorder. Reduction of the electrical activity of the left frontal and bilateral anterior temporal areas with treatment may be through modulation of glutamatergic and GABAergic mechanisms and indicative of valproate's neuroprotective effect. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
Subject
Bipolar Disorder
Event Related Oscillations
Delta Responses
Neurocognitive Functioning
Valproate
GABA/glutamate
Neuroprotection
Mood Disorders
Cognitive-Processes
Schizophrenia
Dysfunction
Valproate
Delta
Gamma
Theta
Potentials
Expression
Bipolar Bozukluk
Olaya İlişkin Salınımlar
Delta Yanıtları
Bilişsel İşleyişi
Valproat
Nöro
Duygudurum Bozuklukları
Bilişsel Süreçler
Şizofreni
Fonksiyon Bozukluğu
Delta
Gama
Teta
Potansiyeller
İfade
URI
http://hdl.handle.net/11413/1153
Collections
  • Makaleler / Articles [147]
  • Scopus Publications [724]
  • WoS Publications [1016]

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İstanbul Kültür University

Hakkında |Politika | Kütüphane | İletişim | Send Feedback | Admin

Istanbul Kültür University, Ataköy Campus E5 Karayolu Üzeri Bakırköy 34158, İstanbul / TURKEY
Copyright © İstanbul Kültür University

Creative Commons Lisansı
IKU Institutional Repository, Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

Designed by  UNIREPOS