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Decrease of evoked delta, theta and alpha coherences in Alzheimer patients during a visual oddball paradigm

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Author
Güntekin, Bahar
Saatçı, Ertuğrul
Yener, Görsev
Type
Article
Date
2008-10-15
Language
en_US
Metadata
Show full item record
Abstract
In this study event related coherence of patients with Alzheimer type of dementia (AD) was analyzed by using a visual oddball paradigm as stimuli. A total of 21 mild probable AD subjects (10 untreated, 11 treated) were compared with a group of 19 healthy controls. The members of the groups had their EEG recorded from 12 electrodes by means of a visual oddball paradigm. The evoked coherence was analyzed for delta (1-3.5 Hz), theta (4-7 Hz) and alpha (8-13 Hz) frequency ranges for inter-hemispheric (F(3)-F(4), C(3)-C(4), T(3)-T(4), T(5)-T(6), P(3)-P(4), O(1)-O(2)) and long range intra-hemi spheric (F(3)-P(3), F(4)-P(4), F(3)-T(5), F(4)-T(6), F(3)-O(1), F(4)-O(2)) electrode pairs. The control group showed higher values of evoked coherence in "delta", "theta" and "alpha" bands in the left fronto-parietal electrode pairs in comparison with the untreated AD group (p < 0.01 for all frequency bands). Furthermore, the control group showed higher values of evoked coherence in the left fronto-parietal electrode pair in theta frequency band (p < 0.01) and higher values of evoked coherence in the right fronto-parietal electrode pair in delta band (p < 0.01) when compared to treated AD group. The only significant difference between the treated and untreated AD groups was in the alpha band. The treated AD group showed higher values of evoked coherence at the left fronto-parietal pair in alpha band in comparison to the untreated AD group (p < 0.01). During a working memory process the coherence in the left fronto-parietal electrode pair (F(3)-P(3)) of AD patients is significantly decreased, thus indicating reduced connectivity between frontal and parietal sites. (c) 2008 Elsevier B.V. All rights reserved.
Subject
alzheimer
evoked coherence
oddball paradigm
event related oscillations
recorded eeg-epograms
neurofibrillary tangles
functional connectivity
reticular-formation
cognitive decline
combined dynamics
auditory pathway
senile plaques
cat brain
disease
alzheimer
uyarılmış tutarlılık
tuhaf paradigma
olaya ilişkin salınımlar
nörofibrillerin
fonksiyonel bağlantı
retiküler oluşumu
bilişsel gerileme
kombine dinamikleri
işitsel yolu
senil plaklar
kedi beyni
hastalık
URI
http://hdl.handle.net/11413/1158
Collections
  • Makaleler / Articles [147]
  • Pubmed Publications [149]
  • Scopus Publications [724]
  • WoS Publications [1016]

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Hakkında |Politika | Kütüphane | İletişim | Send Feedback | Admin

Istanbul Kültür University, Ataköy Campus E5 Karayolu Üzeri Bakırköy 34158, İstanbul / TURKEY
Copyright © İstanbul Kültür University

Creative Commons Lisansı
IKU Institutional Repository, Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

Designed by  UNIREPOS