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dc.contributor.authorAkverdieva, Gulnare
dc.contributor.authorGodjayev, Niftali
dc.contributor.authorAkyüz, Sevim
dc.date.accessioned2016-05-03T12:57:50Z
dc.date.available2016-05-03T12:57:50Z
dc.date.issued2009-01-09
dc.identifier.issn0022-2860
dc.identifier.urihttp://hdl.handle.net/11413/1268
dc.description.abstractA series of peptide T analogs were investigated within the molecular mechanics framework. In order to determine the role of the aminoacid residues in spatial formation of peptide T the conformational peculiarities of the glycine-substituted analogs were investigated. The conformational profiles of some biologically tested analogs of this peptide were determined independently. The received data permit to assess the active form of this peptide. It is characterized by p-turn at the C-terminal physiologically active pentapeptide fragment of peptide molecule. The received results are important for the investigation of the structure-activity relationship and may be used at design of a rigid-molecule drug against HIV. (c) 2008 Elsevier B.V. All rights reserved.tr_TR
dc.language.isoen_UStr_TR
dc.publisherElsevier Science Bv, Po Box 211, 1000 Ae Amsterdam, Netherlandstr_TR
dc.relationJournal Of Molecular Structuretr_TR
dc.subjectPeptide T Analogstr_TR
dc.subjectConformational Analysistr_TR
dc.subjectStructure Activity Relationshiptr_TR
dc.subjectImmunodeficiency Virus Receptortr_TR
dc.subjectHiv Infectivitytr_TR
dc.subjectL-alaninetr_TR
dc.subjectBindingtr_TR
dc.subjectPentapeptidetr_TR
dc.subjectRibonucleasetr_TR
dc.subjectInhibitortr_TR
dc.subjectDynamicstr_TR
dc.subjectHomologytr_TR
dc.subjectGP120tr_TR
dc.subjectKonformasyon Analizitr_TR
dc.subjectYapı Aktivite İlişkisitr_TR
dc.subjectBağışıklık Sistemi Bozucu Virüs Reseptörütr_TR
dc.subjectHIV Enfeksiyonutr_TR
dc.subjectBağlayıcıtr_TR
dc.subjectRibonükleaztr_TR
dc.subjectÖnleyicitr_TR
dc.subjectDinamiktr_TR
dc.subjectHomolojitr_TR
dc.titleComparative Conformational Analysis Of Peptide T Analogstr_TR
dc.typeArticletr_TR
dc.contributor.authorIDTR10127tr_TR
dc.identifier.wos262117600004
dc.identifier.wos262117600004en
dc.identifier.scopus2-s2.0-56849086335
dc.identifier.scopus2-s2.0-56849086335en


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