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Evoked And Event Related Coherence Of Alzheimer Patients Manifest Differentiation Of Sensory-Cognitive Networks

Thumbnail
Author
Başar, Erol
Güntekin, Bahar
Tülay, Elif
Yener, Görsev G.
Type
Article
Date
2010-10-21
Language
en_US
Metadata
Show full item record
Abstract
In previous studies on Alzheimer's patients it was shown that, in frontal and parietal locations, delta and theta responses of AD patients were greatly reduced. The present study analyzed coherence functions in these highly affected frontal and parietal areas. Visual sensory and event related coherences of patients with Alzheimer type dementia (AD) were analyzed comparatively. A total of 38 mild, probable AD subjects (19 untreated, 19 treated with cholinesterase inhibitors) were compared with a group of 19 healthy controls. The sensory evoked coherence and event related target coherences were analyzed for delta (1-3.5 Hz), theta (4-7 Hz), alpha (8-13 Hz), beta (15-30 Hz) and gamma (28-48 Hz) frequency ranges for long-range intra-hemispheric (F-3-P-3, F-4-P-4, F-3-T-5, F-4-T-6, F-3-O-1, F-4-O-2) electrode pairs. The healthy control group showed significantly higher values of event related coherence in "delta", "theta" and "alpha" bands in comparison to the de nova and medicated AD groups (p<0.01 for the delta, theta and alpha) upon application of a target stimuli. In contrast, almost no changes in event related coherences were observed in beta and gamma frequency bands. Furthermore, no differences were recorded between healthy and AD groups upon application of simple light stimuli. Besides this, coherence values upon application of target stimuli were higher than sensory evoked coherence in all groups and in all frequency bands (p<0.01). The cognitive networks of AD patients were highly impaired in comparison to networks activated by sensory stimulation, thus showing separate activation of sensory and cognitive networks. (C) 2010 Elsevier B.V. All rights reserved.
Subject
Alzheimer
Evoked coherence
Event related coherence
Oddball paradigm
Brain oscillation
Cholinergic
time-frequency analysis
working-memory
disease
EEG
impairment
oscillations
potentials
diagnosis
theta
synchronization
Uyarılmış tutarlılık
Olaya ilişkin tutarlılık
acayip paradigma
beyin salınım
kolinerjik
zaman-frekans analizi
çalışan bellek
hastalık
bozulma
salınımlar
potansiyeller
tanı
teta
senkronizasyon
URI
http://hdl.handle.net/11413/1294
Collections
  • Makaleler / Articles [147]
  • Pubmed Publications [149]
  • Scopus Publications [724]
  • WoS Publications [1016]

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Istanbul Kültür University, Ataköy Campus E5 Karayolu Üzeri Bakırköy 34158, İstanbul / TURKEY
Copyright © İstanbul Kültür University

Creative Commons Lisansı
IKU Institutional Repository, Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

Designed by  UNIREPOS