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dc.contributor.authorÖzerdem, Ayşegül
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorAtagün, İlhan
dc.contributor.authorTurp, Bilge
dc.contributor.authorBaşar, Erol
dc.date.accessioned2016-09-02T11:44:07Z
dc.date.available2016-09-02T11:44:07Z
dc.date.issued2011-08
dc.identifier.issn0165-0327
dc.identifier.urihttp://hdl.handle.net/11413/1377
dc.description.abstractBackground: EEG coherence represents the brain's functional connectivity. Synchronous neural gamma oscillations are critical for cortico-cortical communication and large-scale integration of distributed sets of neurons. We investigated long distance gamma (28-48 Hz) coherence in bipolar disorder. Methods: Sensory evoked coherence (EC) and event related coherence (ERC) values for the gamma frequency band during simple light stimulation and visual odd-ball paradigm was assessed in 20 drug-free euthymic bipolar patients in comparison to healthy controls. Groups were compared for the coherence values of the left (F(3)-T(3), F(3)-TP(2), F(3)-P(3), F(3)-O(1)) and right (F(4)-T(4), F(4)-TP(8), F(4)-P(4), F(4)-O(2)) intra-hemispheric electrode pairs by means of a repeated measure analysis of variance (ANOVA) and t-tests. Results: Patients showed significantly lower gamma coherence values in response to target stimuli than the healthy controls between left and right fronto-temporal, as well as between frontal and temporo-parietal electrode pairs. Coherence values for the non-target stimuli were significantly lower in the patients than the healthy controls between frontal and temporo-parietal regions on both right and left sides. EP coherence values did not differ significantly between the groups. Limitations: A relatively small sample size is the major limitation of the study. Conclusions: Bipolar patients present disturbance in functional long-range connectivity between the frontal and temporal as well as temporo-parietal brain structures during a cognitive paradigm requiring attention and immediate recall. The location of the connectivity disturbance corresponds to the underlying neurobiology of executive function, memory and attention impairments in bipolar disorder and raises the question of whether gamma coherence reduction may be a candidate biomarker for bipolar disorder. (C) 2011 Elsevier B.V. All rights reserved.tr_TR
dc.language.isoen_UStr_TR
dc.publisherElsevier Science Bv, Po Box 211, 1000 Ae Amsterdam, Netherlandstr_TR
dc.relationJournal Of Affective Disorderstr_TR
dc.subjectBipolar Disordertr_TR
dc.subjectEuthymiatr_TR
dc.subjectEvent Related Oscillationstr_TR
dc.subjectGamma Coherencetr_TR
dc.subjectNeurocognitive Functioningtr_TR
dc.subjectBiomarkertr_TR
dc.subjectNeuropsychological Deficitstr_TR
dc.subjectSchizophrenia-Patientstr_TR
dc.subjectAlzheimer Patientstr_TR
dc.subjectVisual-Cortextr_TR
dc.subjectHuman Braintr_TR
dc.subjectOscillationstr_TR
dc.subjectDepressiontr_TR
dc.subjectResponsestr_TR
dc.subjectNetworktr_TR
dc.subjectSynchronizationtr_TR
dc.subjectBipolar Bozukluktr_TR
dc.subjectEuthymiatr_TR
dc.subjectOlaya İlişkin Salınımlartr_TR
dc.subjectGama Uyumtr_TR
dc.subjectBilişsel İşleyişitr_TR
dc.subjectBiyomarkertr_TR
dc.subjectNöropsikolojik Açıklarıtr_TR
dc.subjectŞizofreni Hastalarıtr_TR
dc.subjectAlzheimer Hastalarıtr_TR
dc.subjectGörsel Kortekstr_TR
dc.subjectİnsan Beynitr_TR
dc.subjectSlınımlartr_TR
dc.subjectDepresyontr_TR
dc.subjectTepkilertr_TR
dc.subjecttr_TR
dc.subjectSenkronizasyontr_TR
dc.titleReduced long distance gamma (28-48 Hz) coherence in euthymic patients with bipolar disordertr_TR
dc.typeArticletr_TR
dc.contributor.authorIDTR142226tr_TR
dc.contributor.authorIDTR25145tr_TR
dc.contributor.authorIDTR204666tr_TR
dc.contributor.authorIDTR140995tr_TR
dc.identifier.wos293721900004
dc.identifier.wos293721900004en
dc.identifier.scopus2-s2.0-79960322712
dc.identifier.scopus2-s2.0-79960322712en


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