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Lack Of Association Between IL-6 Gene Polymorphisms And Rheumatoid Arthritis In Turkish Population

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Author
Çoker, Ajda
Arman, Ahmet
Sarıöz, Özlem
İnanç, Nevsun
Direskeneli, Rafi Haner
Type
Article
Date
2012-07
Language
en_US
Metadata
Show full item record
Abstract
Inflammatory cytokines play an important role in the pathogenesis of rheumatoid arthritis (RA). One of candidate genes is interleukin-6 (IL-6), and single-nucleotide polymorphisms in the promoter region of IL-6 were found to be associated with RA. The aim of this study was to determine the association between IL-6 promoter polymorphisms (-174, -572, -597) and RA in Turkish population. A total of 425 subjects were recruited into the study (247 healthy controls and 178 RA). The promoter region of IL-6 gene was amplified by PCR using DNAs from patients and the controls, and their PCR products were digested by suitable enzymes. No significant association was found between RA and -174 genotype distribution (P = 0.535) and allele frequency (P = 0.230). There was also no relationship between -572 (P = 0.150) and -597 (P = 0.912) gene polymorphism and RA. Our results suggested that IL-6 gene promoter polymorphisms have no association with RA in Turkish population.
Subject
IL-6
polymorphisms
rheumatoid arthritis
interleukin-6 receptor
cytokine
genotypes
disease
damage
polimorfizmler
romatizmal artrit
interlökin-6 reseptörü
sitokin
genotipler
hastalık
hasar
URI
http://hdl.handle.net/11413/1486
Collections
  • Makaleler / Articles [140]
  • Scopus Publications [724]
  • WoS Publications [1016]

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İstanbul Kültür University

Hakkında |Politika | Kütüphane | İletişim | Send Feedback | Admin

Istanbul Kültür University, Ataköy Campus E5 Karayolu Üzeri Bakırköy 34158, İstanbul / TURKEY
Copyright © İstanbul Kültür University

Creative Commons Lisansı
IKU Institutional Repository, Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

Designed by  UNIREPOS