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dc.contributor.authorÇoker Gürkan, Ajda
dc.contributor.authorIşık, Nihal
dc.contributor.authorArman, Ahmet
dc.contributor.authorAydın Cantürk, İlknur
dc.contributor.authorCandan, Fatma
dc.contributor.authorAktan, Şule
dc.contributor.authorErzaim, Nilüfer
dc.contributor.authorArıcı Düz, Özge
dc.contributor.authorAydın, Tuğrul
dc.contributor.authorTürkeş, Muzaffer
dc.date.accessioned2017-10-23T12:46:40Z
dc.date.available2017-10-23T12:46:40Z
dc.date.issued2013-10
dc.identifier.issn0020-7454
dc.identifier.urihttp://hdl.handle.net/11413/1773
dc.description.abstractBackground: Multiple Sclerosis (MS) is a neurodegenerative disease. It involves inflammation and demyelination. Since cytokines play an important role in the development of MS, genes encoding cytokines such as the Interleukin (IL)-1 family are candidate genes for MS susceptibility. Objective: To determine the relationship between IL-1 gene family and MS in the Turkish population. Methods: A total of 409 MS patients and 256 healthy controls were included in the study. IL-1A -889 (rs1800587), IL-1 RN variable number tandom repeat (VNTR), IL-1B -511 (rs 16944) and IL-1B +3953 (rs 1143634) polymorphisms were investigated from the genomic DNA, obtained via blood samples. Results: No association was found between IL-1A and IL-1RN polymorphisms and susceptibility to MS. However, we have found significantly decreased frequency of IL-1B -511 genotype (p = 0.004) in MS patients compared to controls. In addition, there was a significant association between IL-1B -511 (1/2) genotype and early onset MS (EOMS) (p = 0.0001). Conclusions: Individuals with the 2/2 genotype of IL-1B -511 have significantly decreased incidence of MS, suggesting a protective role for this genotype in the Turkish population. Additionally, IL-1B -511(1/2) genotype was determined as a possible risk factor for EOMS.tr_TR
dc.language.isoen_UStr_TR
dc.publisherInforma Healthcare, Telephone House, 69-77 Paul Street, London Ec2A 4Lq, Englandtr_TR
dc.relationInternational Journal Of Neurosciencetr_TR
dc.subjectdemyelinating diseasetr_TR
dc.subjectinterleukin-1tr_TR
dc.subjectcytokinetr_TR
dc.subjectgenotype distributiontr_TR
dc.subjectdemiyelinizan hastalıktr_TR
dc.subjectinterlökin-1tr_TR
dc.subjectsitokintr_TR
dc.subjectgenotip dağılımıtr_TR
dc.titleMultiple Sclerosis: Association with the Interleukin-1 Gene Family Polymorphisms in the Turkish Populationtr_TR
dc.typeArticletr_TR
dc.contributor.authorID125860tr_TR
dc.contributor.authorID217343tr_TR
dc.contributor.authorID173248tr_TR
dc.contributor.authorID232433tr_TR
dc.identifier.wos324449000006
dc.identifier.wos324449000006en
dc.identifier.scopus2-s2.0-84884395005
dc.identifier.scopus2-s2.0-84884395005en


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