Publication: Association between IL-1RN VNTR, IL-1 beta -511 and IL-6 (-174, -572, -597) Gene Polymorphisms and Urolithiasis
Date
2013
Authors
Çoker Gürkan, Ajda
Arısan, Elif Damla
Palavan Unsal, Narçin
Arısan, Serdar
Sonmez, Nurettin Cem
Journal Title
Journal ISSN
Volume Title
Publisher
Karger, Allschwilerstrasse 10, Ch-4009 Basel, Switzerland
Abstract
Urolithiasis is a common multifactorial urological disorder that is characterized by stone formation. Interleukin (IL)-1 and IL-6 are pro-inflammatory cytokines that might be linked with urolithiasis. The single nucleotide polymorphisms within the IL-1 and IL-6 cytokine genes altered the cytokine expression levels. Our aim was to investigate the potential of IL-1 beta (-511 C>T), IL-6 (-174 G>C, 572 G>C, 597 G>A) and IL-1 RN VNTR gene polymorphisms to be a genetic marker for urinary stone disease. The polymorphisms studied in the promoter regions of IL-1 beta and IL-6 genes did not reveal a strong association with urolithiasis when compared to the control group (p = 0.293, 0.871, 0.921, 0.536, respectively). However, a significant difference was observed between control and patient groups for IL-1 RN VNTR gene polymorphism (chi(2) = 6.131, d.f. = 2, p = 0.047). Our data provide evidence that IL-1RN VNTR gene polymorphism may be involved in the pathogenesis of urinary stone formation, contributing to genetic susceptibility for urolithiasis. (C) 2013 S. Karger AG, Basel
Description
Keywords
Urolithiasis, Interleukin-1, Interleukin-6, Single nucleotide polymorphism, Receptor Antagonist Gene, Calcium-Oxalate Stones, Vitamin-D-Receptor, Kidney-Stones, Interleukin-1-Beta Gene, Tandem Repeat, Nephrolithiasis, Excretion, Intron-2, Protein