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Association between IL-1RN VNTR, IL-1 beta -511 and IL-6 (-174, -572, -597) Gene Polymorphisms and Urolithiasis

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Author
Çoker Gürkan, Ajda
Arısan, Elif Damla
Palavan Unsal, Narçin
Arısan, Serdar
Sonmez, Nurettin Cem
Type
Article
Date
2013
Language
en_US
Metadata
Show full item record
Abstract
Urolithiasis is a common multifactorial urological disorder that is characterized by stone formation. Interleukin (IL)-1 and IL-6 are pro-inflammatory cytokines that might be linked with urolithiasis. The single nucleotide polymorphisms within the IL-1 and IL-6 cytokine genes altered the cytokine expression levels. Our aim was to investigate the potential of IL-1 beta (-511 C>T), IL-6 (-174 G>C, 572 G>C, 597 G>A) and IL-1 RN VNTR gene polymorphisms to be a genetic marker for urinary stone disease. The polymorphisms studied in the promoter regions of IL-1 beta and IL-6 genes did not reveal a strong association with urolithiasis when compared to the control group (p = 0.293, 0.871, 0.921, 0.536, respectively). However, a significant difference was observed between control and patient groups for IL-1 RN VNTR gene polymorphism (chi(2) = 6.131, d.f. = 2, p = 0.047). Our data provide evidence that IL-1RN VNTR gene polymorphism may be involved in the pathogenesis of urinary stone formation, contributing to genetic susceptibility for urolithiasis. (C) 2013 S. Karger AG, Basel
Subject
Urolithiasis
Interleukin-1
Interleukin-6
Single nucleotide polymorphism
Receptor Antagonist Gene
Calcium-Oxalate Stones
Vitamin-D-Receptor
Kidney-Stones
Interleukin-1-Beta Gene
Tandem Repeat
Nephrolithiasis
Excretion
Intron-2
Protein
URI
https://doi.org/10.1159/000345786
https://hdl.handle.net/11413/2013
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  • Makaleler / Articles [140]
  • Pubmed Publications [149]
  • WoS Publications [1016]

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İstanbul Kültür University

Hakkında |Politika | Kütüphane | İletişim | Send Feedback | Admin

Istanbul Kültür University, Ataköy Campus E5 Karayolu Üzeri Bakırköy 34158, İstanbul / TURKEY
Copyright © İstanbul Kültür University

Creative Commons Lisansı
IKU Institutional Repository, Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

Designed by  UNIREPOS