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dc.contributor.authorYener, Görsev
dc.contributor.authorKurt, Pınar
dc.contributor.authorEmek Savaş, Derya Durusu
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorBaşar, Erol
dc.date.accessioned2018-07-11T11:27:24Z
dc.date.available2018-07-11T11:27:24Z
dc.date.issued2013
dc.identifier.issn1387-2877
dc.identifier.urihttps://doi.org/10.3233/JAD-130569
dc.identifier.urihttps://hdl.handle.net/11413/2014
dc.description.abstractMild cognitive impairment (MCI) is considered as a prodromal stage for Alzheimer's disease (AD) in the majority of cases. Event-related oscillations might be used for detection of cognitive deficits. Our group's earlier results showed diminished delta visual and auditory target oscillatory responses in AD, and we investigated whether this prevails for MCI. Eighteen MCI subjects and 18 age-matched healthy elderly controls were investigated. The maximum peak-to-peak amplitudes of oscillatory responses for each subject's averaged oscillatory target responses in delta, theta, and alpha frequency bands upon application of visual oddball paradigm were measured. Repeated measures of ANOVA was used to analyze four locations (frontal, central, parietal, occipital), at three coronal (left, midline, right) sites. Independent t tests were applied for post-hoc analyses. The oddball target delta response (0.5-3.0 Hz) was 26-32% lower in MCI than healthy controls over fronto-central-parietal regions [F(1.34) = 4.562, p = 0.04]. Without a group effect, theta oscillatory responses (4-7 Hz) showed significant differences in coronal electrodes indicating highest values over mid-electrode sites, and a anteriorposterior x coronal effect, being maximum at mid-central. Alpha frequency band analyses indicated no statistical differences. Peak-to-peak amplitudes of visual target delta oscillatory responses were lower in fronto-central-parietal regions in MCI than in healthy controls. This supports our earlier findings in AD, showing hypoactive delta fronto-central-parietal regions during cognitive tasks. These results indicate that event-related oscillations may detect early changes of brain dynamics in MCI, and deserves to be investigated as a candidate biomarker in further studies using multimodal techniques.tr_TR
dc.language.isoen_UStr_TR
dc.publisherIos Press, Nieuwe Hemweg 6B, 1013 Bg Amsterdam, Netherlandstr_TR
dc.relationJournal Of Alzheimers Diseasetr_TR
dc.subjectBiomarkertr_TR
dc.subjectearly diagnosis of Alzheimer's diseasetr_TR
dc.subjectelectroencephalographic rhythmstr_TR
dc.subjectevent-related potentialstr_TR
dc.subjectmild cognitive impairmenttr_TR
dc.subjectoscillationstr_TR
dc.subjectAlzheimers-Diseasetr_TR
dc.subjectTheta-Oscillationstr_TR
dc.subjectBraintr_TR
dc.subjectRhythmstr_TR
dc.subjectEegtr_TR
dc.subjectSynchronizationtr_TR
dc.subjectDiagnosistr_TR
dc.subjectCortextr_TR
dc.subjectElectroencephalographytr_TR
dc.subjectExcitabilitytr_TR
dc.titleReduced Visual Event-Related Delta Oscillatory Responses in Amnestic Mild Cognitive Impairmenttr_TR
dc.typeArticletr_TR
dc.contributor.authorID143760tr_TR
dc.contributor.authorID24351tr_TR
dc.contributor.authorID227002tr_TR
dc.contributor.authorID204666tr_TR
dc.contributor.authorID142226tr_TR
dc.identifier.wos325649500010
dc.identifier.wos325649500010en
dc.identifier.scopus2-s2.0-84881284410
dc.identifier.scopus2-s2.0-84881284410en


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