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Lithium excessively enhances event related beta oscillations in patients with bipolar disorder

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Author
Atagün, Murat İlhan
Güntekin, Bahar
Tan, Devran
Tülay, Emine Elif
Başar, Erol
Type
Article
Date
2015-01-01
Language
en_US
Metadata
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Abstract
Background: Previous resting-state electroencephalography studies have consistently shown that lithium enhances delta and theta oscillations in default mode networks. Cognitive task based networks differ horn resting-state networks and this is the first study to investigate effects or lithium on evoked and event-related beta oscillatory responses of patients with bipolar disorder. Methods: The study included 16 euthymic patients with bipolar disorder on lithium monotherapy, 22 euthymic medication-free patients with bipolar disorder and 21 healthy participants. The maximum peak-to-peak amplitudes were measured for each subject's averaged beta responses (14-28 Hz) in the 0-300 ms time window. Auditory simple and oddball paradigm were presented to obtain evoked and event-related beta oscillatory responses. Results: There were significant differences in beta oscillatory responses between groups (p=0.010). Repeated measures ANOVA revealed location (p=0.007), laterality X group (p=0.043) and stimulus X location (p=0.013) type effects. Serum lithium levels were correlated with beta responses. Limitations: The lithium group had higher number of previous episodes, suggesting that patients of the lithium were more severe cases than patients of the medication-free group. Discussion: Lithium stimulates neuroplastic cascades and beta oscillations become prominent during neuroplastic changes. Excessively enhanced beta oscillatory responses in the lithium-treated patients may be indicative of excessive activation of the neuron groups of the certain cognitive networks and dysfunctional GABAergic modulation during cognitive activity. (C) 2014 Elsevier B.V. All rights reserved.
Subject
Bipolar disorder
Brain oscillations
Event-related oscillations
Lithium
Euthymia
Induced Eeg Changes
Brain Oscillations
Euthymic Patients
Healthy-Subjects
Rating-Scale
Schizophrenia
Mechanisms
Matter
Synchronization
Abnormalities
URI
https://doi.org/10.1016/j.jad.2014.08.024
https://hdl.handle.net/11413/2141
Collections
  • Makaleler / Articles [147]
  • Pubmed Publications [149]
  • Scopus Publications [724]
  • WoS Publications [1016]

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İstanbul Kültür University

Hakkında |Politika | Kütüphane | İletişim | Send Feedback | Admin

Istanbul Kültür University, Ataköy Campus E5 Karayolu Üzeri Bakırköy 34158, İstanbul / TURKEY
Copyright © İstanbul Kültür University

Creative Commons Lisansı
IKU Institutional Repository, Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

Designed by  UNIREPOS