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dc.contributor.authorAtagün, Murat İlhan
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorTan, Devran
dc.contributor.authorTülay, Emine Elif
dc.contributor.authorBaşar, Erol
dc.date.accessioned2018-07-17T08:16:35Z
dc.date.available2018-07-17T08:16:35Z
dc.date.issued2015-01-01
dc.identifier.issn0165-0327
dc.identifier.other1573-2517
dc.identifier.urihttps://doi.org/10.1016/j.jad.2014.08.024
dc.identifier.urihttps://hdl.handle.net/11413/2141
dc.description.abstractBackground: Previous resting-state electroencephalography studies have consistently shown that lithium enhances delta and theta oscillations in default mode networks. Cognitive task based networks differ horn resting-state networks and this is the first study to investigate effects or lithium on evoked and event-related beta oscillatory responses of patients with bipolar disorder. Methods: The study included 16 euthymic patients with bipolar disorder on lithium monotherapy, 22 euthymic medication-free patients with bipolar disorder and 21 healthy participants. The maximum peak-to-peak amplitudes were measured for each subject's averaged beta responses (14-28 Hz) in the 0-300 ms time window. Auditory simple and oddball paradigm were presented to obtain evoked and event-related beta oscillatory responses. Results: There were significant differences in beta oscillatory responses between groups (p=0.010). Repeated measures ANOVA revealed location (p=0.007), laterality X group (p=0.043) and stimulus X location (p=0.013) type effects. Serum lithium levels were correlated with beta responses. Limitations: The lithium group had higher number of previous episodes, suggesting that patients of the lithium were more severe cases than patients of the medication-free group. Discussion: Lithium stimulates neuroplastic cascades and beta oscillations become prominent during neuroplastic changes. Excessively enhanced beta oscillatory responses in the lithium-treated patients may be indicative of excessive activation of the neuron groups of the certain cognitive networks and dysfunctional GABAergic modulation during cognitive activity. (C) 2014 Elsevier B.V. All rights reserved.tr_TR
dc.language.isoen_UStr_TR
dc.publisherElsevier Science Bv, Po Box 211, 1000 AE Amsterdam, Netherlandstr_TR
dc.relationJournal of Affective Disorderstr_TR
dc.subjectBipolar disordertr_TR
dc.subjectBrain oscillationstr_TR
dc.subjectEvent-related oscillationstr_TR
dc.subjectLithiumtr_TR
dc.subjectEuthymiatr_TR
dc.subjectInduced Eeg Changestr_TR
dc.subjectBrain Oscillationstr_TR
dc.subjectEuthymic Patientstr_TR
dc.subjectHealthy-Subjectstr_TR
dc.subjectRating-Scaletr_TR
dc.subjectSchizophreniatr_TR
dc.subjectMechanismstr_TR
dc.subjectMattertr_TR
dc.subjectSynchronizationtr_TR
dc.subjectAbnormalitiestr_TR
dc.titleLithium excessively enhances event related beta oscillations in patients with bipolar disordertr_TR
dc.typeArticletr_TR
dc.contributor.authorID25145tr_TR
dc.contributor.authorID204666tr_TR
dc.contributor.authorID103606tr_TR
dc.contributor.authorID142226tr_TR


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