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What does the broken brain say to the neuroscientist? Oscillations and connectivity in schizophrenia, Alzheimer's disease, and bipolar disorder

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What does the broken brain say to the neuroscientist Oscillations and connectivity in schizophrenia, Alzheimer's disease, and bipolar disorder.pdf (2.070Mb)
Author
Başar, Erol
Mathes, Birgit
Schmiedt-Fehr, Christina
Femir, Banu
Emek Savaş, Derya Durusu
Tülay, Elif
Tan, Devran
Düzgün, Aysel
Güntekin, Bahar
Özerdem, Ayşegül
Yener, Görsev G.
Başar Eroğlu, Canan
Type
Article
Date
2016-05
Language
en_US
Metadata
Show full item record
Abstract
The application of the concept and methods of brain oscillations has been an important research area in neurosciences. In the last decades, besides the application in cognitive processes, the study of changes in brain oscillations in diseases has also become an important focal point of research. In the present paper, some remarkable examples in three different diseases are taken into consideration: 1) schizophrenia (SZ), 2) Alzheimer's disease (AD), 3) bipolar disorders (BD). In the current literature, decreased oscillations in cortical recordings are observed in most of the pathologies. For example, decrease of gamma activity in SZ, decrease of delta activity in almost all diseases, as well as frequency shifts in alpha and the lower frequencies were recorded. However, there are also paradoxical cases in which an increase of oscillatory activities is observed. In BD, whereas alpha activity is greatly decreased, a huge increase of beta activity is observed. Or, in SZ, a paradoxical increase of gamma activity can be observed during cognitive loading. We also observed paradoxical changes in the analysis of connectivity. In AD, we find that alpha, delta, and theta coherences between distant parts of the cortex are greatly decreased, whereas in the gamma band, event-related coherences attain very high values. The comparison of the results and paradoxical changes in diseases may lead to important conclusions related to the web of oscillations and neurotransmitters. In turn, we could gain new insights to approach "brain function", in general. (C) 2016 The Authors. Published by Elsevier B.V.
Subject
Oscillations
Connectivity
Schizophrenia
Alzheimer's disease
Bipolar disorder
Event-Related Oscillations
Mild Cognitive Impairment
Working-Memory
Resting State
Established Schizophrenia
Gamma-Oscillations
Euthymic Patients
High-Risk
Eeg
Responses
URI
https://doi.org/10.1016/j.ijpsycho.2015.02.004
https://hdl.handle.net/11413/2178
Collections
  • Makaleler / Articles [147]
  • Pubmed Publications [149]
  • Scopus Publications [724]
  • WoS Publications [1016]

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İstanbul Kültür University

Hakkında |Politika | Kütüphane | İletişim | Send Feedback | Admin

Istanbul Kültür University, Ataköy Campus E5 Karayolu Üzeri Bakırköy 34158, İstanbul / TURKEY
Copyright © İstanbul Kültür University

Creative Commons Lisansı
IKU Institutional Repository, Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

Designed by  UNIREPOS