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dc.contributor.authorÖğrüç Ildız, Gülce
dc.contributor.authorArslan, M.
dc.contributor.authorÜnsalan, Ozan
dc.contributor.authorAraujo-Andrade, C.
dc.contributor.authorKurt, Ethan
dc.contributor.authorKaratepe, Hasan Turan
dc.contributor.authorYılmaz, Ayberk
dc.contributor.authorBölükbaşı Yalçınkaya, Olcay
dc.contributor.authorHerken, Hasan
dc.date.accessioned2018-07-19T08:06:34Z
dc.date.available2018-07-19T08:06:34Z
dc.date.issued2016-01-05
dc.identifier.issn1386-1425
dc.identifier.urihttps://doi.org/10.1016/j.saa.2014.12.114
dc.identifier.urihttps://hdl.handle.net/11413/2198
dc.description.abstractIn this study, a methodology based on Fourier-transform infrared spectroscopy and principal component analysis and partial least square methods is proposed for the analysis of blood plasma samples in order to identify spectral changes correlated with some biomarkers associated with schizophrenia and bipolarity. Our main goal was to use the spectral information for the calibration of statistical models to discriminate and classify blood plasma samples belonging to bipolar and schizophrenic patients. IR spectra of 30 samples of blood plasma obtained from each, bipolar and schizophrenic patients and healthy control group were collected. The results obtained from principal component analysis (PCA) show a clear discrimination between the bipolar (BP), schizophrenic (SZ) and control group' (CG) blood samples that also give possibility to identify three main regions that show the major differences correlated with both mental disorders (biomarkers). Furthermore, a model for the classification of the blood samples was calibrated using partial least square discriminant analysis (PLS-DA), allowing the correct classification of BP, SZ and CG samples. The results obtained applying this methodology suggest that it can be used as a complimentary diagnostic tool for the detection and discrimination of these mental diseases. (C) 2015 Elsevier B.V. All rights reserved.tr_TR
dc.language.isoen_UStr_TR
dc.publisherPergamon-Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1Gb, Englandtr_TR
dc.relationSpectrochimica Acta Part a-Molecular and Biomolecular Spectroscopytr_TR
dc.subjectFT-IRtr_TR
dc.subjectBipolartr_TR
dc.subjectSchizophreniatr_TR
dc.subjectBlood plasmatr_TR
dc.subjectPCAtr_TR
dc.subjectPLStr_TR
dc.subjectLeast-Squares Regressiontr_TR
dc.subjectInfrared-Spectroscopytr_TR
dc.subjectChemometricstr_TR
dc.titleFT-IR spectroscopy and multivariate analysis as an auxiliary tool for diagnosis of mental disorders: Bipolar and schizophrenia casestr_TR
dc.typeArticletr_TR
dc.contributor.authorID107326tr_TR
dc.contributor.authorID106111tr_TR
dc.contributor.authorID242682tr_TR
dc.contributor.authorID175748tr_TR
dc.contributor.authorID123240tr_TR
dc.identifier.wos365367100069
dc.identifier.wos365367100069en
dc.identifier.scopus2-s2.0-84947025729
dc.identifier.scopus2-s2.0-84947025729en
dc.identifier.pubmed25619859
dc.identifier.pubmed25619859en


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