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dc.contributor.authorLizio, Roberta
dc.contributor.authorDel Percio, Claudio
dc.contributor.authorMarzano, Nicola
dc.contributor.authorSoricelli, Andrea
dc.contributor.authorYener, Görsev G.
dc.contributor.authorBaşar, Erol
dc.contributor.authorMundi, Ciro
dc.contributor.authorDe Rosa, Salvatore
dc.contributor.authorTriggiani, Antonio Ivano
dc.contributor.authorFerri, Raffaele
dc.contributor.authorArnaldi, Dario
dc.contributor.authorNobili, Flavio Mariano
dc.contributor.authorCordone, Susanna
dc.contributor.authorLopez, Susanna
dc.contributor.authorCarducci, Filippo
dc.contributor.authorSanti, Giulia
dc.contributor.authorGesualdo, Loreto
dc.contributor.authorRossini, Paolo M.
dc.contributor.authorCavedo, Enrica
dc.contributor.authorMauri, Margherita
dc.contributor.authorFrisoni, Giovanni B.
dc.contributor.authorBabiloni, Claudio
dc.date.accessioned2018-07-19T14:43:02Z
dc.date.available2018-07-19T14:43:02Z
dc.date.issued2016
dc.identifier.issn1387-2877
dc.identifier.other1875-8908
dc.identifier.urihttps://doi.org/10.3233/JAD-143042
dc.identifier.urihttps://hdl.handle.net/11413/2214
dc.description.abstractHere we presented a single electroencephalographic (EEG) marker for a neurophysiological assessment of Alzheimer's disease (AD) patients already diagnosed by current guidelines. The ability of the EEG marker to classify 127 AD individuals and 121 matched cognitively intact normal elderly (Nold) individuals was tested. Furthermore, its relationship to AD patients' cognitive status and structural brain integrity was examined. Low-resolution brain electromagnetic tomography (LORETA) freeware estimated cortical sources of resting state eyes-closed EEG rhythms. The EEG marker was defined as the ratio between the activity of parieto-occipital cortical sources of delta (2-4 Hz) and low-frequency alpha (8-10.5 Hz) rhythms. Results showed 77.2% of sensitivity in the recognition of the AD individuals; 65% of specificity in the recognition of the Nold individuals; and 0.75 of area under the receiver-operating characteristic curve. Compared to the AD subgroup with the EEG maker within one standard deviation of the Nold mean (EEG-), the AD subgroup with EEG+ showed lower global cognitive status, as revealed by Mini-Mental State Evaluation score, and more abnormal values of white-matter and cerebrospinal fluid normalized volumes, as revealed by structural magnetic resonance imaging. We posit that cognitive and functional status being equal, AD patients with EEG+ should receive special clinical attention due to a neurophysiological "frailty". EEG+ label can be also used in clinical trials (i) to form homogeneous groups of AD patients diagnosed by current guidelines and (ii) as end-point to evaluate intervention effects.tr_TR
dc.language.isoen_UStr_TR
dc.publisherIOS Press, Nieuwe Hemweg 6B, 1013 Bg Amsterdam, Netherlandstr_TR
dc.relationJournal of Alzheimers Diseasetr_TR
dc.subjectAlpha rhythmstr_TR
dc.subjectAlzheimer's diseasetr_TR
dc.subjectdelta rhythmstr_TR
dc.subjectelectroencephalographytr_TR
dc.subjectlow resolution brain electromagnetic tomography (LORETA)tr_TR
dc.subjectneurophysiological assessmenttr_TR
dc.subjectMild Cognitive Impairmenttr_TR
dc.subjectBrain Electromagnetic Tomographytr_TR
dc.subjectEvent-Related Desynchronizationtr_TR
dc.subjectTranscranial Magnetic Stimulationtr_TR
dc.subjectQuantitative Eegtr_TR
dc.subjectVascular Dementiatr_TR
dc.subjectCortical Sourcestr_TR
dc.subjectDiagnostic-Criteriatr_TR
dc.subjectElectrical-Activitytr_TR
dc.subjectParkinsons-Diseasetr_TR
dc.titleNeurophysiological Assessment of Alzheimer's Disease Individuals by a Single Electroencephalographic Markertr_TR
dc.typeArticletr_TR
dc.contributor.authorID143760tr_TR
dc.contributor.authorID142226tr_TR
dc.identifier.wos364409100018
dc.identifier.wos364409100018en
dc.identifier.scopus2-s2.0-84948690979
dc.identifier.scopus2-s2.0-84948690979en
dc.identifier.pubmed26444753
dc.identifier.pubmed26444753en


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