• Home
  • About
  • Policies
  • Contact
    • Türkçe
    • English
  • English 
    • Türkçe
    • English
  • Login
Advanced Search
View Item 
  •   Home
  • Fen Edebiyat Fakültesi / Faculty of Letters and Sciences
  • Moleküler Biyoloji ve Genetik / Molecular Biology and Genetics
  • Makaleler / Articles
  • View Item
  •   Home
  • Fen Edebiyat Fakültesi / Faculty of Letters and Sciences
  • Moleküler Biyoloji ve Genetik / Molecular Biology and Genetics
  • Makaleler / Articles
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Evaluation of biological activities of Physalis peruviana ethanol extracts and expression of Bcl-2 genes in HeLa cells

Thumbnail
View/Open
Evaluation of biological activities of Physalis peruviana ethanol extracts and expression of Bcl-2 genes in HeLa cells.pdf (1.003Mb)
Author
Çakır, Özgür
Pekmez, Murat
Cepni, Elif
Candar, Bilgin
Fidan, Kerem
Type
Article
Date
2014
Language
en_US
Metadata
Show full item record
Abstract
Physalis species are used in folk medicine for phytotherapeutic properties. The extracts of medicinal plants are known to possess cytotoxic and chemopreventative compounds. In this study we investigated antibacterial, antioxidant, DNA damage preventative properties of Physalis peruviana (golden berry) on leaf and shoot ethanol extracts and their effects on cytotoxicity of HeLa cells and expression of apoptotic pathway genes. Among the tested bacteria for antibacterial activity, maximum inhibition zone was determined in Lactococcus lactis. The phenolic content was found higher in leaf extracts than shoot extracts. The antioxidant activity showed the highest TEAC values of the leaf (2 mg/mL) and the shoot (0.5 mg/mL) extracts as 0.291 +/- 0.04 and 0.192 +/- 0.015, respectively. In DNA damage prevention assay both leaf and shoot extracts, especially 30 and 20 mu g/mL concentrations, exhibited significant protection against DNA damage-induced by hydroxyl radical generated by Fenton reaction. Our results suggest that leaf and shoot extracts possess cytotoxic effect on HeLa cells when applied as 100 mu g/mL concentration. Also mRNA expression analysis showed the alteration of antiapoptotic genes, so the results suggest that P. peruviana ethanol extracts induce apoptotic cell death and should be investigated for identification of active compounds and their mechanisms of action.
Subject
Bcl-2
antibacterial
antioxidant
DNA damage
HeLa
Physalis
Antibacterial Activity
Antioxidant Capacity
Induced Apoptosis
U937 Cells
Cancer
Plants
Proliferation
Angulata
Proteins
Growth
URI
https://doi.org/10.1590/fst.2014.0060
https://hdl.handle.net/11413/2293
Collections
  • Makaleler / Articles [140]
  • Scopus Publications [724]
  • WoS Publications [1016]

İstanbul Kültür University

Hakkında |Politika | Kütüphane | İletişim | Send Feedback | Admin

Istanbul Kültür University, Ataköy Campus E5 Karayolu Üzeri Bakırköy 34158, İstanbul / TURKEY
Copyright © İstanbul Kültür University

Creative Commons Lisansı
IKU Institutional Repository, Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

Designed by  UNIREPOS

İKU Kütüphane


Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsTypeLanguageBy PublisherRightsPubmedScopusWoSThis CollectionBy Issue DateAuthorsTitlesSubjectsTypeLanguageBy PublisherRightsPubmedScopusWoS

My Account

Login

İstanbul Kültür University

Hakkında |Politika | Kütüphane | İletişim | Send Feedback | Admin

Istanbul Kültür University, Ataköy Campus E5 Karayolu Üzeri Bakırköy 34158, İstanbul / TURKEY
Copyright © İstanbul Kültür University

Creative Commons Lisansı
IKU Institutional Repository, Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

Designed by  UNIREPOS