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dc.contributor.authorUslan, Canan
dc.contributor.authorDurmuş İşleyen, Naciye
dc.contributor.authorÖztürk, Yetkin
dc.contributor.authorTuranlı Yıldız, Burcu
dc.contributor.authorÇakar, Zeynep Petek
dc.contributor.authorGöksel Şahin, Meltem
dc.contributor.authorDurmuş, Mahmut
dc.contributor.authorHepüzer Gürsel, Yeşim
dc.contributor.authorSesalan, Behice Şebnem
dc.date.accessioned2018-07-25T08:23:44Z
dc.date.available2018-07-25T08:23:44Z
dc.date.issued2018-01
dc.identifier.issn1088-4246
dc.identifier.other1099-1409
dc.identifier.urihttps://doi.org/10.1142/S1088424617500729
dc.identifier.urihttps://hdl.handle.net/11413/2325
dc.description.abstractA poly(ethylene glycol) (PEG)-conjugated silicon(IV) phthalocyanine axially substituted with (PEG1000) chains (SiPc-PEG) was synthesized, and this novel phthalocyanine was characterized by H-1-NMR, FT-IR and UV-Vis spectrophotometric methods. Elemental analysis data were beneficial for the evaluation of the chemical structure of the new compound. The total number of (O-CH2-CH2 units was calculated as 44 and the structure of the new PEG-conjugated silicon phthalocyanine was determined by the use of integral areas in H-1-NMR spectrum and the ratio of SiPc: PEG1000 was found as 1:2. The photophysical and photochemical properties were determined in both DMSO and aqueous solutions. In addition, the photocytotoxicity of the novel PEG-conjugated silicon(IV) phthalocyanine was also examined by testing against human cervical-carcinoma (HeLa) and hepato-carcinoma cells (HuH-7). The IC50 value for the SiPc-PEG compound was determined as 0.28 mu M for HeLa cells and 0.4 mu M for HuH-7 cells. These results imply that HeLa cells are apparently more responsive to photodynamic therapy (PDT) treatment by SiPc-PEG than HuH-7 cells at low concentrations (up to 0.5 mu M) of the studied photosensitizer. Additionally, SiPc-PEG showed antibacterial activity against Escherichia coli at 48 h of incubation, the viabilities of E. coli cultures exposed to 1000 mu g/mL and 2500 mu g/mL SiPc-PEG concentration were reduced by about 90%, and the additional growth inhibitory effect of photoactivation was also observed clearly at these efficient concentrations. To conclude, the novel compound may have a high potential for photodynamic therapy.tr_TR
dc.language.isoen_UStr_TR
dc.publisherWorld Sci Publ Co Inc, 27 Warren St, Ste 401-402, Hackensack, Nj 07601 USAtr_TR
dc.relationJournal of Porphyrins and Phthalocyaninestr_TR
dc.subjectPEG-conjugated silicon phthalocyaninetr_TR
dc.subjectantibacterial effecttr_TR
dc.subjectphotocytotoxicitytr_TR
dc.subjectantitumoral activitytr_TR
dc.subjectphotodynamic therapytr_TR
dc.subjectHalogenated Silicon(Iv) Phthalocyaninestr_TR
dc.subjectPoly(Ethylene Glycol) Chainstr_TR
dc.subjectBovine Serum-Albumintr_TR
dc.subjectBiological-Propertiestr_TR
dc.subjectHela-Cellstr_TR
dc.subjectPhotochemical Propertiestr_TR
dc.subjectZinc Phthalocyaninestr_TR
dc.subjectPhotophysical Propertiestr_TR
dc.subjectMetal Phthalocyaninestr_TR
dc.subjectPhotosensitizerstr_TR
dc.titleA novel of PEG-conjugated phthalocyanine and evaluation of its photocytotoxicity and antibacterial properties for photodynamic therapytr_TR
dc.typeArticletr_TR
dc.contributor.authorID114785tr_TR
dc.contributor.authorID34499tr_TR
dc.contributor.authorID10021tr_TR
dc.contributor.authorID238688tr_TR
dc.contributor.authorID33015tr_TR
dc.contributor.authorID202410tr_TR
dc.identifier.wos427932100003
dc.identifier.wos427932100003en
dc.identifier.scopus2-s2.0-85040075380
dc.identifier.scopus2-s2.0-85040075380en


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