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dc.contributorFen Edebiyat Fakültesi / Faculty of Letters and Sciences Fizik / Physicstr_TR
dc.contributor.authorAkyüz, Sevim
dc.contributor.authorDavies, J. Eric D.
dc.date.accessioned2018-09-04T11:25:47Z
dc.date.available2018-09-04T11:25:47Z
dc.date.issued1993-01-14
dc.identifier4tr_TR
dc.identifier4tr_TR
dc.identifier4tr_TR
dc.identifier.urihttps://doi.org/10.1016/0924-2031(93)87039-V
dc.identifier.urihttps://hdl.handle.net/11413/2623
dc.description.abstractThe perturbations induced by melittin and cholesterol on the molecular organization of dimyristoyl-l-α-phosphatidylcholine (DMPC) bilayers, depending on the temperature and concentrations of both melittin and cholesterol, were studied using FT-IR spectrometry. Analysis of the amide I and amide II bands of melittin indicates that melittin exists as a monomer at all temperatures in the DMPC-melittin system (lipid:protein molar ratio R = 14:1) and in DMPC-cholesterol-melittin dispersions (R = 14 and 25) for low cholesterol concentrations (10 mol%). However in the DMPC-cholesterol-melittin systems with high cholesterol (20 mol%) and high melittin (R = 14) concentrations, melittin is found to be in a tetrameric form at T > Tm. The melittin-induced effects in DMPC bilayers containing a low melittin concentration (R = 25) are found to decrease on addition of cholesterol (10 or 20 mol%). Cholesterol, however, has the opposite effect in DMPC-cholesterol-melittin systems containing high cholesterol (20 mol%) and high melittin concentrations (R = 14), i.e., and increased lipid-protein interaction. Cholesterol- and melittin-induced effects on the spectral features of the phospholipid are discussed.tr_TR
dc.language.isoen_UStr_TR
dc.publisherElseviertr_TR
dc.relationVibrational Spectroscopytr_TR
dc.subjectInfrared spectrometrytr_TR
dc.subjectCholesteroltr_TR
dc.subjectFourier transformtr_TR
dc.subjectMelittintr_TR
dc.subjectMolecular organizationtr_TR
dc.subjectPhospholipid bilayerstr_TR
dc.titleTemperature-dependent Fourier transform infrared spectra of phospholipid bilayers: melittin- and cholesterol-induced effects on molecular organizationtr_TR
dc.typeArticletr_TR
dc.contributor.authorID10127tr_TR


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