Show simple item record

dc.contributor.authorArisan, Elif Damla
dc.contributor.authorOBAKAN YERLIKAYA, PINAR
dc.contributor.authorÇoker Gürkan , Ajda
dc.contributor.authorPalavan Unsal, Narcin
dc.date.accessioned2020-03-05T13:39:11Z
dc.date.available2020-03-05T13:39:11Z
dc.date.issued2016
dc.identifier.isbn978-953-51-2726-0
dc.identifier.isbn978-953-51-2727-7
dc.identifier.urihttps://hdl.handle.net/11413/6284
dc.description.abstractAutophagy is fundamental, evolutionary conserved physiological process at molecular level which targets long-lived cytosolic proteins and organelles to be recycled through lysosomal degradation. Diminished autophagic activity caused cellular stress in many organisms following aging, and inhibition of autophagy in model organisms causes degenerative changes and pathologic diseases observed with high incidence ratio generally in older ages. Consequently the delayed senescence or increased longevity in model organisms often stimulate autophagy, and autophagy inhibition compromises anti-aging effects. The cytoprotective function of autophagy is presented in various human diseases such as lung, liver, cardiovascular diseases, neurodegeneration, myopathies, cancer, stroke, infections and metabolic diseases which are found associated with autophagic targets. These pathologies are defined with their age-dependent characteristics, is not fully understood that how autophagy network regulates metabolism and may cause diseases in age-related manner. In this book chapter, we are going to discuss the autophagy and aging relationship in three different parts. In the first section autophagy and aging relationship is going to be presented through explaining responsible signalling network. The autophagy and age-related neurological disorders, genetic basis of age-dependent diseases and the functional role of autophagy is going to be discussed in the second and third part of the chapter.
dc.language.isoen_UStr_TR
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectAutophagy
dc.subjectAging
dc.subjectMetabolism
dc.subjectDiseases
dc.subjectSirtuins
dc.subjectAMPKa
dc.subjectOtofaji
dc.subjectYaşlanma
dc.subjectMetabolizma
dc.subjectHastalıklar
dc.titleAging-related diseases and autophagy
dc.typeBook chaptertr_TR
dc.relation.journalAutophagy in Current Trends in Celluar Physiologytr_TR
local.journal.startpage15tr_TR
local.journal.endpage48tr_TR
dc.identifier.wos000403813700003
dc.identifier.wos403813700003en


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 United States
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States